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The gut-adipose-liver axis in the metabolic syndrome


Konrad, Daniel; Wueest, Stephan (2014). The gut-adipose-liver axis in the metabolic syndrome. Physiology, 29(5):304-313.

Abstract

Obesity is associated with altered gut microbiota composition and impaired gut barrier function. These changes, together with interrelated mesenteric adipose tissue inflammation, result in increased release of pro-inflammatory cytokines, bacteria-derived factors, and lipids into the portal circulation, promoting the development of (hepatic) insulin resistance. Herein, the potential impact of obesity-related changes in gut and visceral adipose tissue biology on the development of insulin resistance and Type 2 diabetes is reviewed.

Abstract

Obesity is associated with altered gut microbiota composition and impaired gut barrier function. These changes, together with interrelated mesenteric adipose tissue inflammation, result in increased release of pro-inflammatory cytokines, bacteria-derived factors, and lipids into the portal circulation, promoting the development of (hepatic) insulin resistance. Herein, the potential impact of obesity-related changes in gut and visceral adipose tissue biology on the development of insulin resistance and Type 2 diabetes is reviewed.

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11 citations in Web of Science®
11 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Children's Hospital Zurich > Medical Clinic
Dewey Decimal Classification:610 Medicine & health
Date:September 2014
Deposited On:17 Nov 2014 17:14
Last Modified:05 Apr 2016 18:31
Publisher:American Physiological Society
ISSN:1548-9221
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1152/physiol.00014.2014
PubMed ID:25180260

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