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Helping Wingless take flight: how WNT proteins are secreted.


Hausmann, G; Bänziger, C; Basler, K (2007). Helping Wingless take flight: how WNT proteins are secreted. Nature Reviews. Molecular Cell Biology, 8(4):331-336.

Abstract

How functional WNT proteins are made and how their secretion is regulated is becoming a focal point for the WNT-signalling field. Recently, lipoprotein particles, WNT lipid modifications, the conserved transmembrane protein Wntless (WLS; also known as EVI and SRT) and the retromer complex have been implicated in WNT secretion. Our aim is to synthesize ideas from these new findings for the mechanisms that underlie WNT secretion.

How functional WNT proteins are made and how their secretion is regulated is becoming a focal point for the WNT-signalling field. Recently, lipoprotein particles, WNT lipid modifications, the conserved transmembrane protein Wntless (WLS; also known as EVI and SRT) and the retromer complex have been implicated in WNT secretion. Our aim is to synthesize ideas from these new findings for the mechanisms that underlie WNT secretion.

Citations

75 citations in Web of Science®
76 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed
Communities & Collections:07 Faculty of Science > Institute of Molecular Life Sciences
Dewey Decimal Classification:570 Life sciences; biology
Language:English
Date:2007
Deposited On:11 Feb 2008 12:20
Last Modified:05 Apr 2016 12:16
Publisher:Nature Publishing Group
ISSN:1471-0072
Publisher DOI:10.1038/nrm2141
PubMed ID:17342185

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