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DNA Cytosine demethylation: are we getting close?


Jiricny, J; Menigatti, M (2008). DNA Cytosine demethylation: are we getting close? Cell, 135(7):1167-1169.

Abstract

Whether 5-methylcytosine (meC) can be enzymatically removed from vertebrate DNA has been the subject of extensive study and also some controversy. Rai et al. (2008) now report that cytosine demethylation can be accomplished in a one-cell zebrafish embryo by the combined action of a cytidine deaminase and a thymine DNA glycosylase.

Abstract

Whether 5-methylcytosine (meC) can be enzymatically removed from vertebrate DNA has been the subject of extensive study and also some controversy. Rai et al. (2008) now report that cytosine demethylation can be accomplished in a one-cell zebrafish embryo by the combined action of a cytidine deaminase and a thymine DNA glycosylase.

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28 citations in Web of Science®
29 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Molecular Cancer Research
07 Faculty of Science > Institute of Molecular Cancer Research
Dewey Decimal Classification:570 Life sciences; biology
Language:English
Date:2008
Deposited On:13 Jan 2009 10:26
Last Modified:05 Apr 2016 12:49
Publisher:Elsevier
ISSN:0092-8674
Publisher DOI:https://doi.org/10.1016/j.cell.2008.12.008
PubMed ID:19109887

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