Affolter, M; Basler, K (2007). The Decapentaplegic morphogen gradient: from pattern formation to growth regulation. Nature Reviews. Genetics, 8(9):663-674.
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Morphogens have been linked to numerous developmental processes, including organ patterning and the control of organ size. Here we review how different experimental approaches have led to an unprecedented level of molecular knowledge about the patterning role of the Drosophila melanogaster morphogen Decapentaplegic (DPP, the homologue of vertebrate bone morphogenetic protein, or BMP), the first validated secreted morphogen. In addition, we discuss how little is known about the role of the DPP morphogen in the control of organ growth and organ size. Continued efforts to elucidate the role of DPP in D. melanogaster is likely to shed light on this fundamental question in the near future.
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|Item Type:||Journal Article, refereed|
|Communities & Collections:||07 Faculty of Science > Institute of Molecular Life Sciences|
|DDC:||570 Life sciences; biology|
|Deposited On:||11 Feb 2008 12:20|
|Last Modified:||27 Nov 2013 21:11|
|Publisher:||Nature Publishing Group|
|Additional Information:||Embargo for accepted manuscript expires in March 2008|
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