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Swine IFITM proteins potently inhibit influenza A virus replication


Lanz, C; Yangüez, E; Andenmatten, D; Stertz, S (2015). Swine IFITM proteins potently inhibit influenza A virus replication. Journal of Virology, 89(1):863-869.

Abstract

Human IFITMs were identified as restriction factors of influenza A virus (IAV). Given the important role of pigs in the zoonotic cycle of IAV we cloned swine IFITMs (swIFITM) and found two IFITM1-like proteins, one homologue of IFITM2 and one of IFITM3. We show that swIFITM2 and swIFITM3 localize to endosomes and display potent antiviral activity. Knockdown of swIFITMs strongly reduced virus inhibition by interferon establishing the swIFITMs as potent restriction factors in porcine cells.

Human IFITMs were identified as restriction factors of influenza A virus (IAV). Given the important role of pigs in the zoonotic cycle of IAV we cloned swine IFITMs (swIFITM) and found two IFITM1-like proteins, one homologue of IFITM2 and one of IFITM3. We show that swIFITM2 and swIFITM3 localize to endosomes and display potent antiviral activity. Knockdown of swIFITMs strongly reduced virus inhibition by interferon establishing the swIFITMs as potent restriction factors in porcine cells.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Medical Virology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:English
Date:2015
Deposited On:05 Dec 2014 10:26
Last Modified:05 Apr 2016 18:34
Publisher:American Society for Microbiology
ISSN:0022-538X
Funders:Swiss National Science Foundation 159 (31003A_135278), Novartis Research Foundation to SSt
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1128/JVI.02516-14
PubMed ID:25320322
Permanent URL: https://doi.org/10.5167/uzh-101518

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