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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-10161

von Känel, R; Hepp, U; Traber, R; Kraemer, B; Mica, L; Keel, M; Mausbach, B T; Schnyder, U (2008). Measures of endothelial dysfunction in plasma of patients with posttraumatic stress disorder. Psychiatry Research, 158(3):363-373.

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Abstract

Posttraumatic stress disorder (PTSD) confers an increased cardiovascular risk. In 14 otherwise healthy patients with PTSD and in 14 age- and gender-matched non-PTSD controls, we investigated whether the categorical diagnosis of PTSD and severity of PTSD symptom clusters (i.e. re-experiencing, avoidance, arousal, and overall score) would be associated with plasma concentrations of three markers of endothelial dysfunction [soluble tissue factor (sTF), von Willebrand factor (VWF), and soluble intercellular adhesion molecule (sICAM)-1]. Compared with controls, patients had significantly higher sTF; this difference became nonsignificant when controlling for psychological distress. VWF and sICAM-1 levels were not significantly different between patients and controls. In the entire sample virtually all PTSD symptom clusters correlated significantly and positively with sTF and VWF but not with sICAM-1. The correlation between symptoms of re-experiencing and sTF was significantly different between patients and controls. Controlling for symptoms of anxiety and depression (i.e. psychological distress) rendered most associations between PTSD symptom clusters and sTF nonsignificant, whereas controlling for age retained significance of associations with VWF. Posttraumatic stress showed a continuous relationship with sTF and VWF, with the former relationship being partly affected by psychological distress. This suggests one mechanism by which posttraumatic stress could contribute to atherosclerosis.

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Psychiatry and Psychotherapy
04 Faculty of Medicine > University Hospital Zurich > Division of Surgical Research
DDC:610 Medicine & health
Language:English
Date:2008
Deposited On:14 Jan 2009 08:53
Last Modified:27 Nov 2013 22:22
Publisher:Elsevier
ISSN:0165-1781
Publisher DOI:10.1016/j.psychres.2006.12.003
PubMed ID:18252265
Citations:Web of Science®. Times Cited: 28
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