Quick Search:

uzh logo
Browse by:
bullet
bullet
bullet
bullet

Zurich Open Repository and Archive

Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-1019

Liu, Q A; Hengartner, M O (1998). Candidate adaptor protein CED-6 promotes the engulfment of apoptotic cells in C. elegans. Cell, 93(6):961-972.

[img]
Preview
PDF
507kB

View at publisher

Abstract

The rapid engulfment (phagocytosis) of cells undergoing programmed cell death (apoptosis) is a fundamental biological process that is not well understood. Here we report the cloning and functional characterization of ced-6, a gene specifically required for the engulfment of apoptotic cells in the nematode C. elegans. The CED-6 protein contains a phosphotyrosine binding domain at its N terminus and a proline/serine-rich region in its C-terminal half. Genetic mosaic analysis demonstrates that ced-6 acts within engulfing cells. We also show that ced-6 can promote the engulfment of cells at both early and late stages of apoptosis. Our data suggest that CED-6 is an adaptor molecule acting in a signal transduction pathway that specifically mediates the recognition and engulfment of apoptotic cells.

Citations

Altmetrics

Downloads

56 downloads since deposited on 11 Feb 2008
15 downloads since 12 months

Detailed statistics

Additional indexing

Item Type:Journal Article, refereed
Communities & Collections:07 Faculty of Science > Institute of Molecular Life Sciences
DDC:570 Life sciences; biology
Language:English
Date:12 June 1998
Deposited On:11 Feb 2008 12:20
Last Modified:27 Nov 2013 22:34
Publisher:Elsevier
ISSN:0092-8674
Publisher DOI:10.1016/S0092-8674(00)81202-7
PubMed ID:9635426

Users (please log in): suggest update or correction for this item

Repository Staff Only: item control page