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Biased Estimates of Diminishing-Returns Epistasis? Empirical Evidence Revisited


Berger, David; Postma, Erik (2014). Biased Estimates of Diminishing-Returns Epistasis? Empirical Evidence Revisited. Genetics, 198(4):1417-1420.

Abstract

Empirical evidence for diminishing fitness returns of beneficial mutations supports Fisher's geometric model. We show that a similar pattern emerges through the phenomenon of regression to the mean and that few studies correct for it. Although biases are often small, regression to the mean has overemphasized diminishing returns and will hamper cross-study comparisons unless corrected for.

Empirical evidence for diminishing fitness returns of beneficial mutations supports Fisher's geometric model. We show that a similar pattern emerges through the phenomenon of regression to the mean and that few studies correct for it. Although biases are often small, regression to the mean has overemphasized diminishing returns and will hamper cross-study comparisons unless corrected for.

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4 citations in Web of Science®
3 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Institute of Evolutionary Biology and Environmental Studies
Dewey Decimal Classification:570 Life sciences; biology
590 Animals (Zoology)
Language:English
Date:2014
Deposited On:10 Dec 2014 16:08
Last Modified:05 Apr 2016 18:36
Publisher:Genetics Society of America
ISSN:0016-6731
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1534/genetics.114.169870
Permanent URL: https://doi.org/10.5167/uzh-102135

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