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Humoral immune response to avian influenza vaccination over a six-month period in different species of captive wild birds


Furger, M; Hoop, R; Steinmetz, H W; Eulenberger, U; Hatt, J M (2008). Humoral immune response to avian influenza vaccination over a six-month period in different species of captive wild birds. Avian Diseases, 52(2):222-228.

Abstract

In December 2005, the four major Swiss zoos carried out the vaccination of selected zoo birds with the adjuvant inactivated vaccine H5N2 Nobilis influenza. Pre- and post-vaccination antibody titers were determined either by hemagglutination inhibition (HI) test (non-Galliformes) or by enzyme linked immunosorbent assay (ELISA) (Galliformes) at Week 0, 5, 10, and 26 (Day 0–1, 35–36, 70–71, and 182 respectively) to determine the humoral immune response to H5 antigen. After the first vaccination, the overall geometric mean titer of non-Galliformes was 65 (n 5 142), which increased to 187 (n 5 139) after booster vaccination and dropped to 74 (n 5 65) six months after first vaccination. For the Galliformes group, the mean titers were found to be 2.09 at Week 5 (n 5 119), 3.24 at Week 10 (n 5 113), and 1.20 at Week 26 (n 5 39). Within the non-Galliformes, significant differences in geometric mean titers were found among different species representatives. In general, the flamingos (Phoenicopteriformes) showed a strong response to vaccination, reaching a geometric mean titer of 659 at Week 10, while the Sphenisciformes did not show high antibody titers even after booster vaccination, reaching a maximum geometric mean titer of only 65. Based on the antibody titer profiles of all investigated species, we recommend at least annual revaccination for the species
that we investigated.

Abstract

In December 2005, the four major Swiss zoos carried out the vaccination of selected zoo birds with the adjuvant inactivated vaccine H5N2 Nobilis influenza. Pre- and post-vaccination antibody titers were determined either by hemagglutination inhibition (HI) test (non-Galliformes) or by enzyme linked immunosorbent assay (ELISA) (Galliformes) at Week 0, 5, 10, and 26 (Day 0–1, 35–36, 70–71, and 182 respectively) to determine the humoral immune response to H5 antigen. After the first vaccination, the overall geometric mean titer of non-Galliformes was 65 (n 5 142), which increased to 187 (n 5 139) after booster vaccination and dropped to 74 (n 5 65) six months after first vaccination. For the Galliformes group, the mean titers were found to be 2.09 at Week 5 (n 5 119), 3.24 at Week 10 (n 5 113), and 1.20 at Week 26 (n 5 39). Within the non-Galliformes, significant differences in geometric mean titers were found among different species representatives. In general, the flamingos (Phoenicopteriformes) showed a strong response to vaccination, reaching a geometric mean titer of 659 at Week 10, while the Sphenisciformes did not show high antibody titers even after booster vaccination, reaching a maximum geometric mean titer of only 65. Based on the antibody titer profiles of all investigated species, we recommend at least annual revaccination for the species
that we investigated.

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7 citations in Web of Science®
9 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:05 Vetsuisse Faculty > Institute of Veterinary Bacteriology
05 Vetsuisse Faculty > Veterinary Clinic > Department of Small Animals
Dewey Decimal Classification:570 Life sciences; biology
Language:English
Date:June 2008
Deposited On:20 Jan 2009 15:35
Last Modified:05 Apr 2016 12:49
Publisher:American Association of Avian Pathologists
ISSN:0005-2086
Publisher DOI:https://doi.org/10.1637/8111-091707-Reg.1
PubMed ID:18646450

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