UZH-Logo

Genetic control of programmed cell death and aging in the nematode Caenorhabditis elegans.


Hengartner, M O (1997). Genetic control of programmed cell death and aging in the nematode Caenorhabditis elegans. Experimental Gerontology, 32(4-5):363-374.

Abstract

The nematode Caenorhabditis elegans has been used extensively as a model system for the study of basic biological processes. In this species, apoptosis and aging are both under genetic control. Molecular studies have shown that the death machinery that kills C. elegans cells has remained conserved through evolution and also functions to promote apoptotic death in mammalian cells. At least some of the genes that affect C. elegans life span are also evolutionarily conserved; whether the vertebrate homologs of these genes also influence life span remains to be determined. Although a large number of mutations have been isolated that affect either apoptosis or aging in C. elegans, there is so far no evidence that the genetic pathways that control these processes might overlap.

The nematode Caenorhabditis elegans has been used extensively as a model system for the study of basic biological processes. In this species, apoptosis and aging are both under genetic control. Molecular studies have shown that the death machinery that kills C. elegans cells has remained conserved through evolution and also functions to promote apoptotic death in mammalian cells. At least some of the genes that affect C. elegans life span are also evolutionarily conserved; whether the vertebrate homologs of these genes also influence life span remains to be determined. Although a large number of mutations have been isolated that affect either apoptosis or aging in C. elegans, there is so far no evidence that the genetic pathways that control these processes might overlap.

Citations

18 citations in Web of Science®
17 citations in Scopus®
Google Scholar™

Altmetrics

Additional indexing

Item Type:Journal Article, refereed
Communities & Collections:07 Faculty of Science > Institute of Molecular Life Sciences
Dewey Decimal Classification:570 Life sciences; biology
Language:English
Date:July 1997
Deposited On:11 Feb 2008 12:20
Last Modified:05 Apr 2016 12:16
Publisher:Elsevier
ISSN:0531-5565
Publisher DOI:10.1016/S0531-5565(96)00167-2
PubMed ID:9315441

Download

Full text not available from this repository.View at publisher

TrendTerms

TrendTerms displays relevant terms of the abstract of this publication and related documents on a map. The terms and their relations were extracted from ZORA using word statistics. Their timelines are taken from ZORA as well. The bubble size of a term is proportional to the number of documents where the term occurs. Red, orange, yellow and green colors are used for terms that occur in the current document; red indicates high interlinkedness of a term with other terms, orange, yellow and green decreasing interlinkedness. Blue is used for terms that have a relation with the terms in this document, but occur in other documents.
You can navigate and zoom the map. Mouse-hovering a term displays its timeline, clicking it yields the associated documents.

Author Collaborations