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Evaluation of the i-STAT portable point-of-care analyzer for determination of blood gases and acid-base status in newborn calves


Bleul, U; Götz, E (2014). Evaluation of the i-STAT portable point-of-care analyzer for determination of blood gases and acid-base status in newborn calves. Journal of Veterinary Emergency and Critical Care, 24(5):519-528.

Abstract

OBJECTIVE: To validate the i-STAT, a portable hand-held analyzer that allows point-of-care measurement of blood gases, acid-base, lactate, and other blood variables in food animal practice for analysis of blood samples of newborn calves.
DESIGN: Prospective observational study.
SETTING: University teaching hospital.
MEASUREMENTS AND MAIN RESULTS: A total of 271 venous blood samples were analyzed for PvO2 , PvCO2 , pH, base excess (BE), HCO3 , venous saturation of oxygen (SvO2 ), and total carbon dioxide (TCO2 ) using an i-STAT and a Rapidlab 248 bench top analyzer that served as the reference method. l-lactate was measured using the i-STAT as well as photometrically. Results from the i-STAT and the reference methods were compared. The analytes BE, HCO3 , and TCO2 showed a constant systematic error across the entire range with 2.3, 1.9, and 2.0 mmol/L lower values, respectively, than the values measured by the reference method. Based on the combined inherent imprecision of the 2 analyzers and after correcting the influences of systematic errors, the PvO2 , HCO3 , and SvO2 were within the acceptable limits in 76% to 91% of the cases. Ninety-five percent of the measurements of PvCO2 and BE were within acceptable limits.
CONCLUSIONS: The overall performance of the i-STAT was good except for BE, HCO3 , and TCO2 , thus limiting its usefulness in clinical studies. However this hand-held device allows rapid, reliable, and accurate point-of-care blood analyses and thus can be useful in bovine practice.

OBJECTIVE: To validate the i-STAT, a portable hand-held analyzer that allows point-of-care measurement of blood gases, acid-base, lactate, and other blood variables in food animal practice for analysis of blood samples of newborn calves.
DESIGN: Prospective observational study.
SETTING: University teaching hospital.
MEASUREMENTS AND MAIN RESULTS: A total of 271 venous blood samples were analyzed for PvO2 , PvCO2 , pH, base excess (BE), HCO3 , venous saturation of oxygen (SvO2 ), and total carbon dioxide (TCO2 ) using an i-STAT and a Rapidlab 248 bench top analyzer that served as the reference method. l-lactate was measured using the i-STAT as well as photometrically. Results from the i-STAT and the reference methods were compared. The analytes BE, HCO3 , and TCO2 showed a constant systematic error across the entire range with 2.3, 1.9, and 2.0 mmol/L lower values, respectively, than the values measured by the reference method. Based on the combined inherent imprecision of the 2 analyzers and after correcting the influences of systematic errors, the PvO2 , HCO3 , and SvO2 were within the acceptable limits in 76% to 91% of the cases. Ninety-five percent of the measurements of PvCO2 and BE were within acceptable limits.
CONCLUSIONS: The overall performance of the i-STAT was good except for BE, HCO3 , and TCO2 , thus limiting its usefulness in clinical studies. However this hand-held device allows rapid, reliable, and accurate point-of-care blood analyses and thus can be useful in bovine practice.

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3 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:05 Vetsuisse Faculty > Veterinary Clinic > Department of Farm Animals
Dewey Decimal Classification:570 Life sciences; biology
630 Agriculture
Date:2014
Deposited On:30 Dec 2014 16:22
Last Modified:05 Apr 2016 18:40
Publisher:Wiley-Blackwell Publishing, Inc.
ISSN:1476-4431
Additional Information:This is the accepted version of the following article: [Bleul, U. and Götz, E. (2014), Evaluation of the i-STAT portable point-of-care analyzer for determination of blood gases and acid–base status in newborn calves. Journal of Veterinary Emergency and Critical Care, 24: 519–528. doi: 10.1111/vec.12228], which has been published in final form at [http://onlinelibrary.wiley.com/doi/10.1111/vec.12228/abstract]
Publisher DOI:https://doi.org/10.1111/vec.12228
PubMed ID:25205212
Permanent URL: https://doi.org/10.5167/uzh-102888

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