Hengartner, M O (2000). The biochemistry of apoptosis. Nature, 407(6805):770-776.
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Apoptosis--the regulated destruction of a cell--is a complicated process. The decision to die cannot be taken lightly, and the activity of many genes influence a cell's likelihood of activating its self-destruction programme. Once the decision is taken, proper execution of the apoptotic programme requires the coordinated activation and execution of multiple subprogrammes. Here I review the basic components of the death machinery, describe how they interact to regulate apoptosis in a coordinated manner, and discuss the main pathways that are used to activate cell death.
|Item Type:||Journal Article, refereed, original work|
|Communities & Collections:||07 Faculty of Science > Institute of Molecular Life Sciences|
|DDC:||570 Life sciences; biology|
|Date:||12 October 2000|
|Deposited On:||11 Feb 2008 13:20|
|Last Modified:||23 Nov 2012 13:51|
|Publisher:||Nature Publishing Group|
|WoS Citation Count:||3546|
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