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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-10329

Schmitz, A; Kretschmar, O; Knirsch, W; Woitzek, K; Balmer, C; Tomaske, M; Bauersfeld, U; Weiss, M (2008). Comparison of calculated with measured oxygen consumption in children undergoing cardiac catheterization. Pediatric Cardiology, 29(6):1054-1058.

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Abstract

Our objective was to compare calculated (LaFarge) with measured oxygen consumption (VO(2)) using the AS/3 TM Compact Airway Module M-CAiOVX (Datex-Ohmeda, Helsinki, Finland; AS/3 TM) in children without cardiac shunts in a prospective, observational study. VO(2) was determined at the end of the routine diagnostic and/or interventional catheterization. VO(2 )was calculated according to the formula of LaFarge and Miettinen for each child and compared with the measured VO(2). Data were compared using simple regression and Bland Altman analysis. Fifty-two children aged from 0.5 to 16 years (median, 6.9 years) and weighing 3.4 to 59.4 kg (median, 22.9 kg) were investigated. Calculated VO(2 )values ranged from 59.0 to 230.8 ml/min, and measured VO(2) values from 62.7 to 282.2 ml/min. Comparison of calculated versus measured VO(2) values revealed a significant correlation (r = 0.90, p < 0.0001). Bias and precision were 8.9 and 48.3 ml/min, respectively (95% limits of agreement: -39.4 to 57.2 ml/min). Comparison of calculated VO(2) in children older than 3 years (n = 41), as restricted to the formula, with measured VO(2), revealed a slightly reduced correlation (r = 0.86, p < 0.0001). Bias and precision were 10.0 and 52.5 ml/min, respectively (95% limits of agreement: -42.4 to 62.5 ml/min). We conclude that calculation of VO(2) by the LaFarge formula does not provide reliable values compared to measured values. In clinical routine, measured rather than calculated VO(2) values should be used for the estimation of cardiac output and related variables.

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Children's Hospital Zurich > Clinic for Surgery
04 Faculty of Medicine > University Children's Hospital Zurich > Medical Clinic
DDC:610 Medicine & health
Date:2008
Deposited On:30 Jan 2009 11:45
Last Modified:27 Nov 2013 22:41
Publisher:Springer
ISSN:0172-0643
Publisher DOI:10.1007/s00246-008-9248-6
PubMed ID:18592299
Citations:Web of Science®. Times Cited: 5
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Scopus®. Citation Count: 6

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