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Sexual disparity of copeptin in healthy newborn infants


Burckhardt, Marie-Anne; Wellmann, Maike; Fouzas, Sotirios; Lapaire, Olav; Burkhardt, Tilo; Benzing, Jörg; Bührer, Christoph; Szinnai, Gabor; Wellmann, Sven (2014). Sexual disparity of copeptin in healthy newborn infants. Journal of Clinical Endocrinology & Metabolism, 99(9):E1750-E1753.

Abstract

BACKGROUND: Arginine vasopressin (AVP) regulates water balance and blood pressure and plays a role in social behavioral processes. Healthy adult men as compared with women have higher blood levels of AVP and its C-terminal precursor peptide, copeptin.
OBJECTIVE: The objective of the study was to investigate whether sexual disparity of copeptin is present at birth.
METHODS: In 241 prospectively enrolled healthy newborn infants, 131 boys and 110 girls, plasma copeptin concentrations were measured at birth and on day 3 of life.
RESULTS: Multivariable linear regression analysis revealed stressful delivery (regression coefficient β = .569, P <0.001), acidosis (β = -.347, P < .001), and male gender (β = .132, P < .01) as independent determinants of copeptin at birth. In infants born without stress, that is by primary cesarean section (n = 81), male gender was the sole variable associated with copeptin (β = .286, P < .05), copeptin concentrations being higher in boys [median 5.5 pmol/L (interquartile range 4.4-10.2)] than in girls [4.8 pmol/L (interquartile range 3.6-5.8), P < .05]. At day 3 of life, copeptin was determined independently by postnatal physiological dehydration (β = .485; P < .001) and birth weight (β = .279; P < .01).
CONCLUSION: Sexual disparity of copeptin is already present at birth, indicating increased activation of the AVP system in newborn boys as compared with girls.

BACKGROUND: Arginine vasopressin (AVP) regulates water balance and blood pressure and plays a role in social behavioral processes. Healthy adult men as compared with women have higher blood levels of AVP and its C-terminal precursor peptide, copeptin.
OBJECTIVE: The objective of the study was to investigate whether sexual disparity of copeptin is present at birth.
METHODS: In 241 prospectively enrolled healthy newborn infants, 131 boys and 110 girls, plasma copeptin concentrations were measured at birth and on day 3 of life.
RESULTS: Multivariable linear regression analysis revealed stressful delivery (regression coefficient β = .569, P <0.001), acidosis (β = -.347, P < .001), and male gender (β = .132, P < .01) as independent determinants of copeptin at birth. In infants born without stress, that is by primary cesarean section (n = 81), male gender was the sole variable associated with copeptin (β = .286, P < .05), copeptin concentrations being higher in boys [median 5.5 pmol/L (interquartile range 4.4-10.2)] than in girls [4.8 pmol/L (interquartile range 3.6-5.8), P < .05]. At day 3 of life, copeptin was determined independently by postnatal physiological dehydration (β = .485; P < .001) and birth weight (β = .279; P < .01).
CONCLUSION: Sexual disparity of copeptin is already present at birth, indicating increased activation of the AVP system in newborn boys as compared with girls.

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6 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Obstetrics
04 Faculty of Medicine > University Hospital Zurich > Clinic for Neonatology
Dewey Decimal Classification:610 Medicine & health
Date:September 2014
Deposited On:13 Jan 2015 14:36
Last Modified:05 Apr 2016 18:42
Publisher:Endocrine Society
ISSN:0021-972X
Publisher DOI:https://doi.org/10.1210/jc.2014-2244
PubMed ID:25004250
Permanent URL: https://doi.org/10.5167/uzh-103489

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