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External physical and biochemical stimulation to enhance skeletal muscle bioengineering


Handschin, Christoph; Mortezavi, Ashkan; Plock, Jan; Eberli, Daniel (2015). External physical and biochemical stimulation to enhance skeletal muscle bioengineering. Advanced Drug Delivery Reviews, 82-83:168-175.

Abstract

PURPOSE OF REVIEW: Cell based muscle tissue engineering carries the potential to revert the functional loss of muscle tissue caused by disease and trauma. Although muscle tissue can be bioengineered using various precursor cells, major limitations still remain.
RECENT FINDINGS: In the last decades several cellular pathways playing a crucial role in muscle tissue regeneration have been described. These pathways can be influenced by external stimuli and they not only orchestrate the regenerative process after physiologic wear and muscle trauma, but also play an important part in aging and maintaining the stem cell niche, which is required to maintain long-term muscle function.
SUMMARY: In this review article we will highlight possible new avenues using external physical and biochemical stimulation in order to optimize muscle bioengineering.

PURPOSE OF REVIEW: Cell based muscle tissue engineering carries the potential to revert the functional loss of muscle tissue caused by disease and trauma. Although muscle tissue can be bioengineered using various precursor cells, major limitations still remain.
RECENT FINDINGS: In the last decades several cellular pathways playing a crucial role in muscle tissue regeneration have been described. These pathways can be influenced by external stimuli and they not only orchestrate the regenerative process after physiologic wear and muscle trauma, but also play an important part in aging and maintaining the stem cell niche, which is required to maintain long-term muscle function.
SUMMARY: In this review article we will highlight possible new avenues using external physical and biochemical stimulation in order to optimize muscle bioengineering.

Citations

4 citations in Web of Science®
4 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Urological Clinic
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2015
Deposited On:21 Jan 2015 16:16
Last Modified:05 Apr 2016 18:45
Publisher:Elsevier
ISSN:0169-409X
Publisher DOI:https://doi.org/10.1016/j.addr.2014.10.021
PubMed ID:25453267
Permanent URL: https://doi.org/10.5167/uzh-104129

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