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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-1042

Liu, Y; Hengartner, M O; Herr, W (1999). Selected elements of herpes simplex virus accessory factor HCF are highly conserved in Caenorhabditis elegans. Molecular and Cellular Biology, 19(1):909-915.



HCF is a mammalian nuclear protein that undergoes proteolytic processing and is required for cell proliferation. During productive herpes simplex virus (HSV) infection, the viral transactivator VP16 associates with HCF to initiate HSV gene transcription. Here, we show that the worm Caenorhabditis elegans possesses a functional homolog of mammalian HCF that can associate with and activate the viral protein VP16. The pattern of sequence conservation, however, is uneven. Sequences required for mammalian HCF processing are not present in C. elegans HCF. Furthermore, not all elements of mammalian HCF that are required for promoting cell proliferation are conserved. Nevertheless, unexpectedly, C. elegans HCF can promote mammalian cell proliferation because a region of HCF that is conserved can promote mammalian cell proliferation better than its human counterpart. These results suggest that HCF possesses a highly conserved role in metazoan cell proliferation which is targeted by VP16 to regulate HSV infection. The precise mechanisms, however, by which HCF functions in mammals and worms appear to differ.


17 citations in Web of Science®
17 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed
Communities & Collections:07 Faculty of Science > Institute of Molecular Life Sciences
Dewey Decimal Classification:570 Life sciences; biology
Date:1 January 1999
Deposited On:11 Feb 2008 12:20
Last Modified:05 Apr 2016 12:17
Publisher:American Society for Microbiology (ASM)
Related URLs:http://mcb.asm.org/cgi/content/abstract/19/1/909
PubMed ID:9858614

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