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Steroid use in Crohn's disease


Vavricka, Stephan R; Schoepfer, Alain M; Scharl, Michael; Rogler, Gerhard (2014). Steroid use in Crohn's disease. Drugs, 74(3):313-324.

Abstract

The incidence and prevalence of Crohn's disease are increasing, particularly in the Western world and Asia. Corticosteroids have been used for decades to treat active Crohn's disease and remain the mainstay in the management of moderate-to-severe relapses in Crohn's disease. The use of corticosteroids, despite their efficacy, may be associated with several drawbacks. This review article provides a comprehensive account of the role of corticosteroids in inducing remission in adult patients with Crohn's disease, including aspects such as approaches to corticosteroid sparing and to minimize the risk of corticosteroid dependency, as well as the role of newer corticosteroids such as budesonide in reducing systemic adverse effects.

The incidence and prevalence of Crohn's disease are increasing, particularly in the Western world and Asia. Corticosteroids have been used for decades to treat active Crohn's disease and remain the mainstay in the management of moderate-to-severe relapses in Crohn's disease. The use of corticosteroids, despite their efficacy, may be associated with several drawbacks. This review article provides a comprehensive account of the role of corticosteroids in inducing remission in adult patients with Crohn's disease, including aspects such as approaches to corticosteroid sparing and to minimize the risk of corticosteroid dependency, as well as the role of newer corticosteroids such as budesonide in reducing systemic adverse effects.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Gastroenterology and Hepatology
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:March 2014
Deposited On:11 Feb 2015 11:32
Last Modified:05 Apr 2016 18:49
Publisher:Springer
ISSN:0012-6667
Additional Information:The final publication is available at Springer via http://dx.doi.org/10.1007/s40265-014-0183-y
Publisher DOI:https://doi.org/10.1007/s40265-014-0183-y
PubMed ID:24532122
Permanent URL: https://doi.org/10.5167/uzh-105067

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