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Domínguez, M; Brunner, M; Hafen, E; Basler, K (1996). Sending and receiving the hedgehog signal: control by the Drosophila Gli protein Cubitus interruptus. Science, 272(5268):1621-1625.

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Abstract

Drosophila limb development is organized by interactions between anterior and posterior compartment cells. Posterior cells continuously express and require engrailed (en) and secrete Hedgehog (Hh) protein. Anterior cells express the zinc-finger protein Cubitus interruptus (Ci). It is now shown that anterior cells lacking ci express hh and adopt posterior properties without expressing en. Increased levels of Ci can induce the expression of the Hh target gene decapentaplegic (dpp) in a Hh-independent manner. Thus, expression of Ci in anterior cells controls limb development (i) by restricting hh secretion to posterior cells and (ii) by conferring competence to respond to Hh by mediating the transduction of this signal.

Item Type:Journal Article, refereed
Communities & Collections:07 Faculty of Science > Institute of Zoology (former)
07 Faculty of Science > Institute of Molecular Life Sciences
DDC:570 Life sciences; biology
590 Animals (Zoology)
Language:English
Date:14 June 1996
Deposited On:11 Feb 2008 12:20
Last Modified:27 Nov 2013 19:33
Publisher:American Association for the Advancement of Science (AAAS)
ISSN:0036-8075
Publisher DOI:10.1126/science.272.5268.1621
Related URLs:http://links.jstor.org/sici?sici=0036-8075%2819960614%293%3A272%3A5268%3C1621%3ASARTHS%3E2.0.CO%3B2-F
PubMed ID:8658135
Citations:Web of Science®. Times Cited: 240
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