Kiening, K L; Schoening, W; Unterberg, A W; Stover, J F; Citerio, G; Enblad, P; Nilssons, P (2005). Assessment of the relationship between age and continuous intracranial compliance. In: Poon, W S; Avezaat, C J J; Chan, M T V; Czosnyka, M. Intracranial Pressure and Brain Monitoring XII. Wien: Springer, 293-297.
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The aim of this open, descriptive and prospective study was to determine if the new monitoring parameter "continuous intracranial compliance (cICC)" decreases with age in patients with traumatic brain injury (TBI). 30 patients with severe and moderate TBI (Glasgow Coma Scale score < or = 10) contributing to a European multicenter study, organized by the Brain-IT group, underwent computerized monitoring of blood pressure, intracranial pressure (ICP), cerebral perfusion pressure and cICC. Regression analyses of individual median ICP and median cICC versus patients' age revealed no significant dependency. Median cICC declined significantly with increasing ICP (when median ICP = 10, 20 and 30 mmHg, cICC = 0.64, 0.56 and 0.42 ml/mmHg respectively, p < 0.05). These three ICP groups were then subdivided according to age (0-20, 21-40, 41-60 and 61-80 years). Median cICC declined with age in both high ICP groups (median ICP = 20,30 mmHg). Percentage cICC values below a set pathological threshold of lower than 0.05 ml/mmHg across the four age groups were 28% (0-20 yrs), 59% (21-40 yrs), 60% (41-60 yrs) and 70% (61-80 yrs) respectively. The observed phenomenon of decreased intracranial volume challenge compensation with advancing age may contribute to the well-known fact of a worse outcome in elderly patients after TBI.
|Item Type:||Book Section, refereed, original work|
|Communities & Collections:||04 Faculty of Medicine > University Hospital Zurich > Division of Surgical Intensive Care Medicine|
|Dewey Decimal Classification:||610 Medicine & health|
|Deposited On:||25 Sep 2009 11:32|
|Last Modified:||04 Apr 2012 12:32|
|Series Name:||Acta Neurochirurgica Supplements|
|ISBN:||978-3-211-24336-7 (P) 978-3-211-32318-2 (O)|
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