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Sakowitz, O W; Unterberg, A W; Stover, J F (2002). Neuronal activity determined by quantitative EEG and cortical microdialysis is increased following controlled cortical impact injury in rats. In: Czosnyka, M. Intracranial pressure and brain biochemical monitoring. Wien, 221-223. ISBN 3-211-83776-0.

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Abstract

Following brain injury increased glutamate release is linked to sustained neuronal activation resulting in excitotoxic tissue damage. Isoflurane anesthesia has been shown to decrease electroencephalographic (EEG) activity and extracellular (e.c.) glutamate, possibly attenuating excitotoxic tissue damage. However, based on clinical experience EEG activity can fluctuate despite stable isoflurane concentrations. Therefore, the aims of this study were to investigate the impact of neuronal activity assessed by quantitative EEG on e.c. glutamate during isoflurane anesthesia following controlled cortical impact injury (CCII). In 10 rats balanced anesthesia using isoflurane was induced at 4 hours after CCII. Under steady-state conditions maintaining isoflurane at 1.8 vol%, EEG was recorded for 3 hours. During this period, e.c. glutamate was sampled in the pericontusional cortex by microdialysis. Despite maintaining isoflurane at 1.8 vol%, neuronal activity expressed as low frequency EEG power showed marked fluctuations. Spontaneous increases in neuronal activity coincided with elevated e.c. glutamate levels and vice versa. Overall, EEG power correlated significantly with pathologically elevated e.c. glutamate levels (n = 58; R2 = 0.54; p < 0.05). Despite unchanged isoflurance concentrations fluctuations in neuronal activity were reflected by altered EEG power and e.c. glutamate concentrations. Therefore, neuronal activity needs to be considered for the interpretation of e.c. glutamate levels.

Item Type:Book Section, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Division of Surgical Intensive Care Medicine
DDC:610 Medicine & health
Language:English
Date:2002
Deposited On:18 Sep 2009 08:24
Last Modified:27 Nov 2013 23:15
Publisher:Springer
Series Name:Acta neurochirurgica. Supplementum
Number:81
ISSN:0065-1419
ISBN:3-211-83776-0
Related URLs:https://biblio.unizh.ch/F/?local_base=UZH01&con_lng=GER&func=find-b&find_code=SYS&request=000762495
PubMed ID:12168309
Citations:Web of Science®. Times Cited: 11
Google Scholar™
Scopus®. Citation Count: 11

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