Quick Search:

uzh logo
Browse by:
bullet
bullet
bullet
bullet

Zurich Open Repository and Archive 

Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-10654

Thomale, U W; Kroppenstedt, S N; Beyer, T F; Schaser, K D; Unterberg, A W; Stover, J F (2002). Temporal profile of cortical perfusion and microcirculation after controlled cortical impact injury in rats. Journal of Neurotrauma, 19(4):403-413.

[img]PDF - Registered users only
1523Kb

Abstract

Impaired cerebral perfusion contributes to evolving posttraumatic tissue damage. Spontaneous reversibility of reduced perfusion within the first days after injury could make a persisting impact on secondary tissue damage less likely and needs to be considered for possible therapeutic approaches. The present study was designed to characterize the temporal profile and impact of trauma severity on cortical perfusion and microcirculation during the first 48 h after controlled cortical impact injury (CCI). In 10 rats, pericontusional cortical perfusion and microcirculation using laser Doppler flowmetry (LDF) and orthogonal polarization spectral (OPS) imaging were assessed before, and at 4, 24, and 48 h after CCI. Influence of trauma severity was studied by varying the penetration depth of the impactor rod (0.5 vs. 1 mm), thereby inducing a less and a more severe contusion. Mean arterial blood pressure (MABP), arterial blood gases, and blood glucose were monitored. With unchanged MABP and paCO2, cortical perfusion and microcirculation were significantly impaired during the first 48 h following CCI. Hypoperfusion observed at 4 h related to vasoconstriction and microcirculatory stasis preceded a long-lasting phase of hyperperfusion at 24 and 48 h reflected by vasodilation and increased flow velocity in arterioles and venules. Hyperperfusion was mostly pronounced in rats with a less severe contusion. Following CCI, trauma severity markedly influences changes in pericontusional cortical perfusion and microcirculation. Overall, pericontusional cortical hypoperfusion observed within the early phase preceded a long lasting phase of hyperperfusion up to 48 h after CCI.

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Division of Surgical Intensive Care Medicine
DDC:610 Medicine & health
Language:English
Date:April 2002
Deposited On:18 Sep 2009 11:48
Last Modified:27 Nov 2013 19:02
Publisher:Mary Ann Liebert
ISSN:0897-7151
Publisher DOI:10.1089/08977150252932361
PubMed ID:11990347
Citations:Web of Science®. Times Cited: 22
Google Scholar™

Users (please log in): suggest update or correction for this item

Repository Staff Only: item control page