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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-10672

Stover, J F; Lenzlinger, P M; Stocker, R; Morganti-Kossmann, M C; Imhof, H G; Trentz, O; Kossmann, T (1998). Thiopental in CSF and serum correlates with prolonged loss of cortical activity. European Neurology, 39(4):223-228.

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Barbiturate coma is initiated in brain-injured patients whenever elevated intracranial pressure remains unresponsive to other therapeutical strategies. However, barbiturates alter cortical activity resulting in difficulties in clinical evaluation. Therefore, we investigated the impact of long-term thiopental administration on responsiveness to exteroceptive stimuli in relation to pharmacokinetics of thiopental in CSF and serum. Long-term infusion increases thiopental levels which remain elevated for 6 and 9 days in CSF and serum, respectively, after termination of its administration. Prolonged unresponsiveness to exteroceptive stimuli correlates with persisting thiopental in CSF and serum. Thus, quantitative analysis of thiopental in serum becomes indispensable in predicting the length of drug-induced neurological impairment and in avoiding misinterpretation of the neurological status.


16 citations in Web of Science®
15 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Division of Surgical Intensive Care Medicine
Dewey Decimal Classification:610 Medicine & health
Deposited On:13 Mar 2009 11:46
Last Modified:07 Jul 2016 14:36
Publisher DOI:10.1159/000007938
PubMed ID:9635473

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