Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-10672
Stover, J F; Lenzlinger, P M; Stocker, R; Morganti-Kossmann, M C; Imhof, H G; Trentz, O; Kossmann, T (1998). Thiopental in CSF and serum correlates with prolonged loss of cortical activity. European Neurology, 39(4):223-228.
- Registered users only
View at publisher
Barbiturate coma is initiated in brain-injured patients whenever elevated intracranial pressure remains unresponsive to other therapeutical strategies. However, barbiturates alter cortical activity resulting in difficulties in clinical evaluation. Therefore, we investigated the impact of long-term thiopental administration on responsiveness to exteroceptive stimuli in relation to pharmacokinetics of thiopental in CSF and serum. Long-term infusion increases thiopental levels which remain elevated for 6 and 9 days in CSF and serum, respectively, after termination of its administration. Prolonged unresponsiveness to exteroceptive stimuli correlates with persisting thiopental in CSF and serum. Thus, quantitative analysis of thiopental in serum becomes indispensable in predicting the length of drug-induced neurological impairment and in avoiding misinterpretation of the neurological status.
0 downloads since deposited on 13 Mar 2009
0 downloads since 12 months
|Item Type:||Journal Article, refereed, original work|
|Communities & Collections:||04 Faculty of Medicine > University Hospital Zurich > Division of Surgical Intensive Care Medicine|
|Dewey Decimal Classification:||610 Medicine & health|
|Deposited On:||13 Mar 2009 11:46|
|Last Modified:||27 Nov 2013 18:13|
Users (please log in): suggest update or correction for this item
Repository Staff Only: item control page