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Cloning and sequencing of the cDNA encoding human neurotrypsin.


Proba, K; Gschwend, T P; Sonderegger, P (1998). Cloning and sequencing of the cDNA encoding human neurotrypsin. Biochimica et Biophysica Acta, 1396(2):143-147.

Abstract

cDNA clones encoding human neurotrypsin have been isolated from a human fetal brain cDNA library using a PCR-amplified probe. The assembled cDNA sequence contains a 2625 bp open reading frame encoding a multidomain serine protease with an overall sequence identity of 82.5% to murine neurotrypsin. Surprisingly, the human neurotrypsin exhibits an additional scavenger receptor cysteine-rich repeat.

cDNA clones encoding human neurotrypsin have been isolated from a human fetal brain cDNA library using a PCR-amplified probe. The assembled cDNA sequence contains a 2625 bp open reading frame encoding a multidomain serine protease with an overall sequence identity of 82.5% to murine neurotrypsin. Surprisingly, the human neurotrypsin exhibits an additional scavenger receptor cysteine-rich repeat.

Citations

26 citations in Web of Science®
25 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed
Communities & Collections:04 Faculty of Medicine > Department of Biochemistry
07 Faculty of Science > Department of Biochemistry
Dewey Decimal Classification:570 Life sciences; biology
Uncontrolled Keywords:Human neurotrypsin;, cDNA cloning
Language:English
Date:9 March 1998
Deposited On:11 Feb 2008 12:20
Last Modified:05 Apr 2016 12:17
Publisher:Elsevier
ISSN:0006-3002
Publisher DOI:10.1016/S0167-4781(97)00205-4
PubMed ID:9540828

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