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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-10739

Duschek, S; Schuepbach, D; Schandry, R (2008). Time-locked association between rapid cerebral blood flow modulation and attentional performance. Clinical Neurophysiology, 119(6):1292-1299.

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Abstract

OBJECTIVE: The study investigated relationships between rapid cerebral hemodynamic modulation and attentional performance. Based on former results on complex cognitive functioning, a specific association between the first seconds of the hemodynamic response and performance was hypothesized. METHODS: Using transcranial Doppler sonography, blood flow velocities in the middle cerebral arteries of both hemispheres were recorded in 48 healthy subjects. The applied task comprised motor reactions on a visual stimulus which was preceded by an acoustic warning signal (interstimulus interval 5s). Task-induced hemodynamic changes were assessed second-by-second, and related to reaction time using analysis of variance and linear regression. RESULTS: A right dominant blood flow response was observed. Flow velocity increase in the middle fraction of the interstimulus interval, i.e. seconds 2 and 3 after the cuing signal, significantly correlated with reaction time. This was not the case for the very early and late components of the response. CONCLUSIONS: The results suggest a time-locked association between cerebral blood flow increase and attentional performance. This is in accordance with neurophysiological studies that revealed the closest relationship between brain perfusion and cortical activity during a similar time window. SIGNIFICANCE: The study supports the assumption of a specific, relatively early time interval in which relationships between cerebral blood flow and behavior become apparent.

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Psychiatric University Hospital Zurich > Clinic for Psychiatry, Psychotherapy, and Psychosomatics
DDC:610 Medicine & health
Language:English
Date:2008
Deposited On:21 Jan 2009 07:47
Last Modified:27 Nov 2013 23:21
Publisher:Elsevier
ISSN:1388-2457
Publisher DOI:10.1016/j.clinph.2008.01.102
PubMed ID:18394956
Citations:Web of Science®. Times Cited: 11
Google Scholar™
Scopus®. Citation Count: 14

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