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Expression of the axon growth-related neural adhesion molecule TAG-1/axonin-1 in the adult mouse brain.


Wolfer, D P; Giger, R J; Stagliar, M; Sonderegger, P; Lipp, H P (1998). Expression of the axon growth-related neural adhesion molecule TAG-1/axonin-1 in the adult mouse brain. Anatomy and Embryology, 197(3):177-185.

Abstract

TAG-1/axonin-1 is a neuronal cell adhesion molecule of the immunoglobulin superfamily. It is predominantly expressed during neural development and has been reported to be involved in axonal growth and pathfinding. Here, the expression of TAG-1/axonin-1 was investigated anatomically in the adult mouse brain by in situ hybridization using digoxigenin-labeled cRNA probes. Low levels of TAG-1/axonin-1 could be detected in cerebellar granule cells, in tufted and mitral cells of the olfactory bulb, and in pyramidal cells of area CA1 and CA3 of the hippocampus. We suspect that the expression of TAG-1/axonin-1 in these structures of the adult brain may serve neural plasticity.

TAG-1/axonin-1 is a neuronal cell adhesion molecule of the immunoglobulin superfamily. It is predominantly expressed during neural development and has been reported to be involved in axonal growth and pathfinding. Here, the expression of TAG-1/axonin-1 was investigated anatomically in the adult mouse brain by in situ hybridization using digoxigenin-labeled cRNA probes. Low levels of TAG-1/axonin-1 could be detected in cerebellar granule cells, in tufted and mitral cells of the olfactory bulb, and in pyramidal cells of area CA1 and CA3 of the hippocampus. We suspect that the expression of TAG-1/axonin-1 in these structures of the adult brain may serve neural plasticity.

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23 citations in Web of Science®
24 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed
Communities & Collections:04 Faculty of Medicine > Department of Biochemistry
07 Faculty of Science > Department of Biochemistry
Dewey Decimal Classification:570 Life sciences; biology
Uncontrolled Keywords:Neural plasticity, Hippocampus, Cerebellum, Olfactory bulb, In situ hybridization
Language:English
Date:1 March 1998
Deposited On:11 Feb 2008 12:20
Last Modified:05 Apr 2016 12:17
Publisher:Springer
ISSN:0340-2061
Funders:Swiss National Science Foundation (grants 31-374997-93, 31-42347.94), Human Frontiers Science Program
Publisher DOI:10.1007/s004290050129
PubMed ID:9543336

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