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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-10880

Harris, N L; Spoerri, I; Schopfer, J F; Nembrini, C; Merky, P; Massacand, J; Urban, JF; Lamarre, A; Burki, K; Odermatt, B; Zinkernagel, R M; Macpherson, A J (2006). Mechanisms of neonatal mucosal antibody protection. Journal of Immunology, 177(9):6256-6262.

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Abstract

Following an abrupt transition at birth from the sterile uterus to an environment with abundant commensal and pathogenic microbes, neonatal mammals are protected by maternal Abs at mucosal surfaces. We show in mice that different Ab isotypes work in distinct ways to protect the neonatal mucosal surface. Secretory IgA acts to limit penetration of commensal intestinal bacteria through the neonatal intestinal epithelium: an apparently primitive process that does not require diversification of the primary natural Ab repertoire. In contrast, neonatal protection against the exclusively luminal parasite Heligmosomoides polygyrus required IgG from primed females. This immune IgG could either be delivered directly in milk or retrotransported via neonatal Fc receptor from the neonatal serum into the intestinal lumen to exert its protective effect.

Item Type:Journal Article, refereed, original work
Communities & Collections:05 Vetsuisse Faculty > Institute of Laboratory Animal Science
04 Faculty of Medicine > Institute of Laboratory Animal Science
DDC:570 Life sciences; biology
610 Medicine & health
Language:English
Date:November 2006
Deposited On:23 Mar 2009 08:44
Last Modified:20 Apr 2014 07:47
Publisher:American Association of Immunologists
ISSN:0022-1767
Free access at:PubMed ID. An embargo period may apply.
Publisher DOI:10.4049/jimmunol.177.9.6256
PubMed ID:17056555
Citations:Web of Science®. Times Cited: 58
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Scopus®. Citation Count: 67

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