Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-10880
Harris, N L; Spoerri, I; Schopfer, J F; Nembrini, C; Merky, P; Massacand, J; Urban, JF; Lamarre, A; Burki, K; Odermatt, B; Zinkernagel, R M; Macpherson, A J (2006). Mechanisms of neonatal mucosal antibody protection. Journal of Immunology, 177(9):6256-6262.
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Following an abrupt transition at birth from the sterile uterus to an environment with abundant commensal and pathogenic microbes, neonatal mammals are protected by maternal Abs at mucosal surfaces. We show in mice that different Ab isotypes work in distinct ways to protect the neonatal mucosal surface. Secretory IgA acts to limit penetration of commensal intestinal bacteria through the neonatal intestinal epithelium: an apparently primitive process that does not require diversification of the primary natural Ab repertoire. In contrast, neonatal protection against the exclusively luminal parasite Heligmosomoides polygyrus required IgG from primed females. This immune IgG could either be delivered directly in milk or retrotransported via neonatal Fc receptor from the neonatal serum into the intestinal lumen to exert its protective effect.
|Item Type:||Journal Article, refereed, original work|
|Communities & Collections:||05 Vetsuisse Faculty > Institute of Laboratory Animal Science|
04 Faculty of Medicine > Institute of Laboratory Animal Science
|DDC:||570 Life sciences; biology|
610 Medicine & health
|Deposited On:||23 Mar 2009 09:44|
|Last Modified:||27 Nov 2013 21:21|
|Publisher:||American Association of Immunologists|
|Free access at:||PubMed ID. An embargo period may apply.|
|Citations:||Web of Science®. Times Cited: 56|
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