Hintsch, G; Zurlinden, A; Meskenaite, V; Steuble, M; Fink-Widmer, K; Kinter, J; Sonderegger, P (2002). The calsyntenins--a family of postsynaptic membrane proteins with distinct neuronal expression patterns. Molecular and Cellular Neuroscience, 21(3):393-409.
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We have identified two novel postsynaptic membrane proteins that are highly similar to calsyntenin-1 in their extracellular parts but vary considerably in their cytoplasmic segment. Calsyntenin-1 has recently been identified in our lab as a postsynaptic membrane protein with a highly acidic cytoplasmic segment with putative Ca(2+)-binding capacity (Vogt et al., 2001, Mol. Cell. Neurosci. 17: 151-166). Based on their structural similarity to calsyntenin-1, we have called the novel proteins calsyntenin-2 and -3, respectively. By immunoelectron microscopy, the calsyntenin protein family was localized in the postsynaptic membrane of excitatory central nervous system (CNS) synapses. In situ hybridization analysis revealed that calsyntenin-1 was abundant in most neurons of the CNS with relatively little variation in its expression level. Calsyntenin-2 and -3 expressions varied much more with highest levels in GABAergic neurons. Based on their distinct expression patterns and the differences in their cytoplasmic segments, we suggest a cell-type-specific functional role for the three calsyntenins in excitatory synaptic transmission.
|Item Type:||Journal Article, refereed|
|Communities & Collections:||04 Faculty of Medicine > Institute of Biochemistry|
07 Faculty of Science > Institute of Biochemistry
|DDC:||570 Life sciences; biology|
|Date:||01 November 2002|
|Deposited On:||11 Feb 2008 13:20|
|Last Modified:||23 Nov 2012 15:41|
|Funders:||Swiss National Science Foundation, NCCR on Neural Plasticity and Repair, Olga Mayenfisch-Foundation, Jubiläumsstiftung der Rentenanstalt/Swiss Life, EMDO-Foundation, Prionics AG|
|WoS Citation Count:||34|
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