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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-11070

Zhao, J; Leonard, C; Gemsenjäger, E; Heitz, P U; Moch, H; Odermatt, B (2008). Differentiation of human follicular thyroid adenomas from carcinomas by gene expression profiling. Oncology Reports, 19(2):329-337.

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It is difficult to distinguish benign from malignant follicular thyroid tumors by histological or cytological examination. The goal of this study was to reveal gene expression variations between benign and malignant follicular lesions of the thyroid gland. We investigated gene expression profiles from 24 follicular thyroid tumors (12 carcinomas and 12 adenomas) and 13 normal thyroid tissues using high-density human cDNA arrays. The identification of gene expression changes was based on signal intensity ratios of tumor versus normal thyroid parenchyma. Expression patterns of a set of known genes were found to be significantly different between follicular adenomas and follicular carcinomas. Our results demonstrate a potential use of gene expression profiling for differentiating benign from malignant follicular thyroid tumors. A detailed investigation of the differentially expressed genes could give new insights into molecular pathways of malignant transformation of thyroid follicular neoplasm and may help to develop a molecular tool for the preoperative differential diagnosis.


9 citations in Web of Science®
8 citations in Scopus®
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1 download since deposited on 05 Feb 2009
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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Institute of Surgical Pathology
Dewey Decimal Classification:610 Medicine & health
Deposited On:05 Feb 2009 07:59
Last Modified:05 Apr 2016 12:52
Official URL:http://www.spandidos-publications.com/or/article.jsp?article_id=or_19_2_329
PubMed ID:18202778

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