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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-1110

Suter, D M; Pollerberg, G E; Buchstaller, A; Giger, R J; Dreyer, W J; Sonderegger, P (1995). Binding between the neural cell adhesion molecules axonin-1 and Nr-CAM/Bravo is involved in neuron-glia interaction. Journal of Cell Biology, 131(4):1067-1081.



Neural cell adhesion molecules of the immunoglobulin superfamily mediate cellular interactions via homophilic binding to identical molecules and heterophilic binding to other family members or structurally unrelated cell-surface glycoproteins. Here we report on an interaction between axonin-1 and Nr-CAM/Bravo. In search for novel ligands of axonin-1, fluorescent polystyrene microspheres conjugated with axonin-1 were found to bind to peripheral glial cells from dorsal root ganglia. By antibody blockage experiments an axonin-1 receptor on the glial cells was identified as Nr-CAM. The specificity of the interaction was confirmed with binding studies using purified axonin-1 and Nr-CAM. In cultures of dissociated dorsal root ganglia antibodies against axonin-1 and Nr-CAM perturbed the formation of contacts between neurites and peripheral glial cells. Together, these results implicate a binding between axonin-1 of the neuritic and Nr-CAM of the glial cell membrane in the early phase of axon ensheathment in the peripheral nervous system.

Item Type:Journal Article, refereed
Communities & Collections:04 Faculty of Medicine > Department of Biochemistry
07 Faculty of Science > Department of Biochemistry
DDC:570 Life sciences; biology
Date:1 November 1995
Deposited On:11 Feb 2008 12:20
Last Modified:28 Nov 2013 01:17
Publisher:Rockefeller University Press
Publisher DOI:10.1083/jcb.131.4.1067
Related URLs:http://www.jcb.org/cgi/reprint/131/4/1067
PubMed ID:7490283
Citations:Web of Science®. Times Cited: 74
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