Quick Search:

uzh logo
Browse by:
bullet
bullet
bullet
bullet

Zurich Open Repository and Archive

Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-1110

Suter, D M; Pollerberg, G E; Buchstaller, A; Giger, R J; Dreyer, W J; Sonderegger, P (1995). Binding between the neural cell adhesion molecules axonin-1 and Nr-CAM/Bravo is involved in neuron-glia interaction. Journal of Cell Biology, 131(4):1067-1081.

[img]
Preview
PDF
4MB

View at publisher

Abstract

Neural cell adhesion molecules of the immunoglobulin superfamily mediate cellular interactions via homophilic binding to identical molecules and heterophilic binding to other family members or structurally unrelated cell-surface glycoproteins. Here we report on an interaction between axonin-1 and Nr-CAM/Bravo. In search for novel ligands of axonin-1, fluorescent polystyrene microspheres conjugated with axonin-1 were found to bind to peripheral glial cells from dorsal root ganglia. By antibody blockage experiments an axonin-1 receptor on the glial cells was identified as Nr-CAM. The specificity of the interaction was confirmed with binding studies using purified axonin-1 and Nr-CAM. In cultures of dissociated dorsal root ganglia antibodies against axonin-1 and Nr-CAM perturbed the formation of contacts between neurites and peripheral glial cells. Together, these results implicate a binding between axonin-1 of the neuritic and Nr-CAM of the glial cell membrane in the early phase of axon ensheathment in the peripheral nervous system.

Citations

74 citations in Web of Science®
71 citations in Scopus®
Google Scholar™

Altmetrics

Downloads

40 downloads since deposited on 11 Feb 2008
12 downloads since 12 months

Detailed statistics

Additional indexing

Item Type:Journal Article, refereed
Communities & Collections:04 Faculty of Medicine > Department of Biochemistry
07 Faculty of Science > Department of Biochemistry
DDC:570 Life sciences; biology
Language:English
Date:1 November 1995
Deposited On:11 Feb 2008 12:20
Last Modified:28 Nov 2013 01:17
Publisher:Rockefeller University Press
ISSN:0021-9525
Publisher DOI:10.1083/jcb.131.4.1067
Related URLs:http://www.jcb.org/cgi/reprint/131/4/1067
PubMed ID:7490283

Users (please log in): suggest update or correction for this item

Repository Staff Only: item control page