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Determination of MIC Distribution and Epidemiological Cut-Off Values for Bedaquiline and Delamanid in Mycobacterium tuberculosis Using MGIT 960/TB eXiST


Keller, Peter M; Hömke, Rico; Ritter, Claudia; Valsesia, Giorgia; Bloemberg, Guido V; Böttger, Erik C (2015). Determination of MIC Distribution and Epidemiological Cut-Off Values for Bedaquiline and Delamanid in Mycobacterium tuberculosis Using MGIT 960/TB eXiST. Antimicrobial Agents and Chemotherapy, 59(7):4352-4355.

Abstract

Bedaquiline and delamanid have recently been approved by the regulatory authorities for treatment of multidrug-resistant tuberculosis (MDR-TB). Antimicrobial susceptibility testing is not established for either substance. On the basis of MGIT 960/TB eXiST we determined a mean bedaquiline MIC of wild-type strains of 0.65 mg/L (median 0.4 mg/L) and an epidemiological cut-off (ECOFF) of 1.6 mg/L; for delamanid a mean wild-type MIC of 0.013 mg/L (median 0.01 mg/L) and an ECOFF of 0.04 mg/L was determined.

Bedaquiline and delamanid have recently been approved by the regulatory authorities for treatment of multidrug-resistant tuberculosis (MDR-TB). Antimicrobial susceptibility testing is not established for either substance. On the basis of MGIT 960/TB eXiST we determined a mean bedaquiline MIC of wild-type strains of 0.65 mg/L (median 0.4 mg/L) and an epidemiological cut-off (ECOFF) of 1.6 mg/L; for delamanid a mean wild-type MIC of 0.013 mg/L (median 0.01 mg/L) and an ECOFF of 0.04 mg/L was determined.

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4 citations in Web of Science®
2 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Medical Microbiology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Date:4 May 2015
Deposited On:19 Jun 2015 13:52
Last Modified:05 Apr 2016 19:17
Publisher:American Society for Microbiology
ISSN:0066-4804
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1128/AAC.00614-15
PubMed ID:25941226

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