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Optimizing radiation dose by using advanced modelled iterative reconstruction in high-pitch coronary CT angiography


Gordic, Sonja; Desbiolles, Lotus; Sedlmair, Martin; Manka, Robert; Plass, André; Schmidt, Bernhard; Husarik, Daniela B; Maisano, Francesco; Wildermuth, Simon; Alkadhi, Hatem; Leschka, Sebastian (2016). Optimizing radiation dose by using advanced modelled iterative reconstruction in high-pitch coronary CT angiography. European Radiology, 26(2):459-468.

Abstract

PURPOSE: To evaluate the potential of advanced modeled iterative reconstruction (ADMIRE) for optimizing radiation dose of high-pitch coronary CT angiography (CCTA).
METHODS: High-pitch 192-slice dual-source CCTA was performed in 25 patients (group 1) according to standard settings (ref. 100 kVp, ref. 270 mAs/rot). Images were reconstructed with filtered back projection (FBP) and ADMIRE (strength levels 1-5). In another 25 patients (group 2), high-pitch CCTA protocol parameters were adapted according to results from group 1 (ref. 160 mAs/rot), and images were reconstructed with ADMIRE level 4. In ten patients of group 1, vessel sharpness using full width at half maximum (FWHM) analysis was determined. Image quality was assessed by two independent, blinded readers.
RESULTS: Interobserver agreements for attenuation and noise were excellent (r = 0.88/0.85, p < 0.01). In group 1, ADMIRE level 4 images were most often selected (84 %, 21/25) as preferred data set; at this level noise reduction was 40 % compared to FBP. Vessel borders showed increasing sharpness (FWHM) at increasing ADMIRE levels (p < 0.05). Image quality in group 2 was similar to that of group 1 at ADMIRE levels 2-3. Radiation dose in group 2 (0.3 ± 0.1 mSv) was significantly lower than in group 1 (0.5 ± 0.3 mSv; p < 0.05).
CONCLUSIONS: In a selected population, ADMIRE can be used for optimizing high-pitch CCTA to an effective dose of 0.3 mSv.
KEY POINTS: Advanced modeled IR (ADMIRE) reduces image noise up to 50 % as compared to FBP. Coronary artery vessel borders show an increasing sharpness at higher ADMIRE levels. High-pitch CCTA with ADMIRE is possible at a radiation dose of 0.3 mSv.

Abstract

PURPOSE: To evaluate the potential of advanced modeled iterative reconstruction (ADMIRE) for optimizing radiation dose of high-pitch coronary CT angiography (CCTA).
METHODS: High-pitch 192-slice dual-source CCTA was performed in 25 patients (group 1) according to standard settings (ref. 100 kVp, ref. 270 mAs/rot). Images were reconstructed with filtered back projection (FBP) and ADMIRE (strength levels 1-5). In another 25 patients (group 2), high-pitch CCTA protocol parameters were adapted according to results from group 1 (ref. 160 mAs/rot), and images were reconstructed with ADMIRE level 4. In ten patients of group 1, vessel sharpness using full width at half maximum (FWHM) analysis was determined. Image quality was assessed by two independent, blinded readers.
RESULTS: Interobserver agreements for attenuation and noise were excellent (r = 0.88/0.85, p < 0.01). In group 1, ADMIRE level 4 images were most often selected (84 %, 21/25) as preferred data set; at this level noise reduction was 40 % compared to FBP. Vessel borders showed increasing sharpness (FWHM) at increasing ADMIRE levels (p < 0.05). Image quality in group 2 was similar to that of group 1 at ADMIRE levels 2-3. Radiation dose in group 2 (0.3 ± 0.1 mSv) was significantly lower than in group 1 (0.5 ± 0.3 mSv; p < 0.05).
CONCLUSIONS: In a selected population, ADMIRE can be used for optimizing high-pitch CCTA to an effective dose of 0.3 mSv.
KEY POINTS: Advanced modeled IR (ADMIRE) reduces image noise up to 50 % as compared to FBP. Coronary artery vessel borders show an increasing sharpness at higher ADMIRE levels. High-pitch CCTA with ADMIRE is possible at a radiation dose of 0.3 mSv.

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2 citations in Web of Science®
4 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Cardiovascular Surgery
04 Faculty of Medicine > University Hospital Zurich > Clinic for Diagnostic and Interventional Radiology
04 Faculty of Medicine > Institute of Biomedical Engineering
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2016
Deposited On:16 Jul 2015 12:38
Last Modified:05 Apr 2016 19:19
Publisher:Springer
ISSN:0938-7994
Publisher DOI:https://doi.org/10.1007/s00330-015-3862-5
PubMed ID:26037718

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