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Elevated hepcidin serum level in response to inflammatory and iron signals in exercising athletes is independent of moderate supplementation with vitamin C and E


Díaz, Víctor; Peinado, Ana B; Barba-Moreno, Laura; Altamura, Sandro; Butragueño, Javier; González-Gross, Marcela; Alteheld, Birgit; Stehle, Peter; Zapico, Augusto G; Muckenthaler, Martina U; Gassmann, Max (2015). Elevated hepcidin serum level in response to inflammatory and iron signals in exercising athletes is independent of moderate supplementation with vitamin C and E. Physiological Reports, 3(8):e12475.

Abstract

Iron deficiency among endurance athletes is of major concern for coaches, physicians, and nutritionists. Recently, it has been observed that hepcidin, the master regulator of iron metabolism, was upregulated after exercise and was found to be related to interleukin-6 (IL-6) elevation. In this study performed on noniron deficient and well-trained runners, we observed that hepcidin concentrations remain elevated in response to inflammatory and iron signals despite a 28-days supplementation period with vitamins C (500 mg/day) and E (400 IU/day).

Iron deficiency among endurance athletes is of major concern for coaches, physicians, and nutritionists. Recently, it has been observed that hepcidin, the master regulator of iron metabolism, was upregulated after exercise and was found to be related to interleukin-6 (IL-6) elevation. In this study performed on noniron deficient and well-trained runners, we observed that hepcidin concentrations remain elevated in response to inflammatory and iron signals despite a 28-days supplementation period with vitamins C (500 mg/day) and E (400 IU/day).

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Center for Integrative Human Physiology
05 Vetsuisse Faculty > Institute of Veterinary Physiology
Dewey Decimal Classification:570 Life sciences; biology
Language:English
Date:August 2015
Deposited On:27 Aug 2015 15:11
Last Modified:05 Sep 2016 10:55
Publisher:Wiley Open Access
ISSN:2051-817X
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.14814/phy2.12475
PubMed ID:26243212
Permanent URL: https://doi.org/10.5167/uzh-112502

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