Quick Search:

uzh logo
Browse by:

Zurich Open Repository and Archive

Distler, J; Distler, O (2008). Novel treatment approaches to fibrosis in scleroderma. Rheumatic Disease Clinics of North America, 34(1):145-159.

Full text not available from this repository.

View at publisher


The molecular mechanisms leading to tissue fibrosis were only poorly understood in the past, and even today the cause or trigger of systemic sclerosis is still unknown. Remarkable breakthrough findings have been obtained regarding the identification of key molecules, key cellular mechanisms, and key intracellular signaling cascades, which mediate the perpetuation of fibrosis rather than trigger it. These findings have true translational implications, because modifiers of these key mediators and key mechanisms are often in clinical use in other disease indications, such as cancer. This article summarizes the clinical and preclinical evidence of examples of these novel antifibrotic treatment approaches in systemic sclerosis, including stem cell transplantation, modifiers of transforming growth factor-beta1 signaling, intravenous immunoglobulins, tyrosine kinase inhibitors, and histone deacetylase inhibitors.


10 citations in Web of Science®
11 citations in Scopus®
Google Scholar™


Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Rheumatology Clinic and Institute of Physical Medicine
Dewey Decimal Classification:610 Medicine & health
Deposited On:22 Jan 2009 15:14
Last Modified:05 Apr 2016 12:53
Publisher DOI:10.1016/j.rdc.2007.12.003
PubMed ID:18329537

Users (please log in): suggest update or correction for this item

Repository Staff Only: item control page