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A comparative investigation of mussel-mimetic sealants for fetal membrane repair


Perrini, Michela; Barrett, Devin; Ochsenbein-Koelble, Nicole; Zimmermann, Roland; Messersmith, Phillip; Ehrbar, Martin (2016). A comparative investigation of mussel-mimetic sealants for fetal membrane repair. Journal of the Mechanical Behavior of Biomedical Materials, 58:57-64.

Abstract

Towards the prevention of iatrogenic preterm premature rupture of the fetal membrane, two mussel-mimetic tissue adhesives (cT and cPEG) have been compared and qualified as possible sealants for membrane repair. Monotonic and cyclic inflation tests of repaired fetal membranes were carried out in order to investigate the performance of the glues under quasi-static, fast, and repeated loading. Finite element simulations of repaired and inflated synthetic membranes allowed to compare cT and cPEG under large deformations. Both adhesives seal the membrane well, resisting pressures higher than the intra-uterine baseline. Only under repeated mechanical load, as well as under fast and acute deformation of the membrane, the sealing performance has deteriorated. Even though cT loses adhesion to the deformed membrane, it is able to withstand high deformations and pressures without rupturing, while cPEG breaks.

Towards the prevention of iatrogenic preterm premature rupture of the fetal membrane, two mussel-mimetic tissue adhesives (cT and cPEG) have been compared and qualified as possible sealants for membrane repair. Monotonic and cyclic inflation tests of repaired fetal membranes were carried out in order to investigate the performance of the glues under quasi-static, fast, and repeated loading. Finite element simulations of repaired and inflated synthetic membranes allowed to compare cT and cPEG under large deformations. Both adhesives seal the membrane well, resisting pressures higher than the intra-uterine baseline. Only under repeated mechanical load, as well as under fast and acute deformation of the membrane, the sealing performance has deteriorated. Even though cT loses adhesion to the deformed membrane, it is able to withstand high deformations and pressures without rupturing, while cPEG breaks.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Obstetrics
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2016
Deposited On:16 Sep 2015 15:12
Last Modified:29 Apr 2016 01:00
Publisher:Elsevier
ISSN:1878-0180
Publisher DOI:https://doi.org/10.1016/j.jmbbm.2015.07.009
PubMed ID:26255212
Permanent URL: https://doi.org/10.5167/uzh-112771

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