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Cardiopulmonary exercise testing in mild heart failure: impact of the mode of exercise on established prognostic predictors


Maeder, M T; Wolber, T; Ammann, P; Myers, J; Brunner-La Rocca, H P; Hack, D; Riesen, W; Rickli, H (2008). Cardiopulmonary exercise testing in mild heart failure: impact of the mode of exercise on established prognostic predictors. Cardiology, 110(2):135-141.

Abstract

OBJECTIVES: In patients with heart failure (HF), peak oxygen consumption (peak VO(2)), the relationship between minute ventilation and carbon dioxide production (VE/VCO(2) slope) and heart rate recovery (HRR) are established prognostic predictors. However, treadmill exercise has been shown to elicit higher peak VO(2) values than bicycle exercise. We sought to assess whether the VE/VCO(2) slope and HRR in HF also depend on the exercise mode. METHODS: Twenty-one patients with mild HF on chronic beta-blocker therapy underwent treadmill and bicycle cardiopulmonary exercise testing for measurement of peak VO(2) and the VE/VCO(2) slope. In patients with sinus rhythm (n = 16), HRR at 1 (HRR-1) and 2 min (HRR-2) after exercise termination was assessed. RESULTS: Peak VO(2) was higher during treadmill as compared with bicycle testing (21.7 +/- 4.6 vs. 19.6 +/- 3.4 ml/kg/min; p = 0.006). HRR-1 tended to be slower (15 bpm, interquartile range 8-19, vs. 18 bpm, interquartile range 11-22; p = 0.16), and HRR-2 was significantly slower after treadmill exercise (26 bpm, interquartile range 20-39, vs. 31 bpm, interquartile range 22-41; p = 0.04). In contrast, VE/VCO(2) slope values did not differ between the test modes (32.9 +/- 5.5 vs. 32.3 +/- 5.0; p = 0.56). CONCLUSIONS: In contrast to peak VO(2) and HRR, the VE/VCO(2) slope is not affected by the exercise mode in patients with mild HF.

OBJECTIVES: In patients with heart failure (HF), peak oxygen consumption (peak VO(2)), the relationship between minute ventilation and carbon dioxide production (VE/VCO(2) slope) and heart rate recovery (HRR) are established prognostic predictors. However, treadmill exercise has been shown to elicit higher peak VO(2) values than bicycle exercise. We sought to assess whether the VE/VCO(2) slope and HRR in HF also depend on the exercise mode. METHODS: Twenty-one patients with mild HF on chronic beta-blocker therapy underwent treadmill and bicycle cardiopulmonary exercise testing for measurement of peak VO(2) and the VE/VCO(2) slope. In patients with sinus rhythm (n = 16), HRR at 1 (HRR-1) and 2 min (HRR-2) after exercise termination was assessed. RESULTS: Peak VO(2) was higher during treadmill as compared with bicycle testing (21.7 +/- 4.6 vs. 19.6 +/- 3.4 ml/kg/min; p = 0.006). HRR-1 tended to be slower (15 bpm, interquartile range 8-19, vs. 18 bpm, interquartile range 11-22; p = 0.16), and HRR-2 was significantly slower after treadmill exercise (26 bpm, interquartile range 20-39, vs. 31 bpm, interquartile range 22-41; p = 0.04). In contrast, VE/VCO(2) slope values did not differ between the test modes (32.9 +/- 5.5 vs. 32.3 +/- 5.0; p = 0.56). CONCLUSIONS: In contrast to peak VO(2) and HRR, the VE/VCO(2) slope is not affected by the exercise mode in patients with mild HF.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Cardiology
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2008
Deposited On:28 Jan 2009 11:34
Last Modified:07 Jul 2016 09:13
Publisher:Karger
ISSN:0008-6312
Publisher DOI:10.1159/000110493
PubMed ID:17975313
Permanent URL: http://doi.org/10.5167/uzh-11281

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