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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-11367

Fuchs, B; Zumstein, M; Regenfelder, F; Steinmann, P; Fuchs, T; Husmann, K; Hellermann, J; Jost, B; Hodler, J; Born, W; Gerber, C (2008). Upregulation of alpha-skeletal muscle actin and myosin heavy polypeptide gene products in degenerating rotator cuff muscles. Journal of Orthopaedic Research, 26(7):1007-1011.

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Abstract

Impaired function of shoulder muscles, resulting from rotator cuff tears, is associated with abnormal deposition of fat in muscle tissue, but corresponding cellular and molecular mechanisms, likely reflected by altered gene expression profiles, are largely unknown. Here, an analysis of muscle gene expression was carried out by semiquantitative RT-PCR in total RNA extracts of supraspinatus biopsies collected from 60 patients prior to shoulder surgery. A significant increase of alpha-skeletal muscle actin (p = 0.0115) and of myosin heavy polypeptide 1 (p = 0.0147) gene transcripts was observed in parallel with progressive fat deposition in the muscle, assessed on parasagittal T1-weighted turbo-spin-echo magnetic resonance images according to Goutallier. Upregulation of alpha-skeletal muscle actin and of myosin heavy polypeptide-1 has been reported to be associated with increased muscle tissue metabolism and oxidative stress. The findings of the present study, therefore, challenge the hypothesis that increased fat deposition in rotator cuff muscle after injury reflects muscle degeneration.

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3 citations in Web of Science®
3 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Balgrist University Hospital, Swiss Spinal Cord Injury Center
DDC:610 Medicine & health
Language:English
Date:July 2008
Deposited On:23 Jan 2009 14:22
Last Modified:27 Nov 2013 23:02
Publisher:Wiley-Blackwell
ISSN:0736-0266
Publisher DOI:10.1002/jor.20577
PubMed ID:18327800

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