UZH-Logo

Maintenance Infos

SUVpeak performance in Lung Cancer: Comparison to Average SUV from 40 Hottest Voxels


Laffon, Eric; Burger, Irene A; Lamare, Frederic; de Clermont-Gallerande, Henri; Marthan, Roger (2016). SUVpeak performance in Lung Cancer: Comparison to Average SUV from 40 Hottest Voxels. Journal of Nuclear Medicine, 57(1):85-88.

Abstract

The performance of an average standard uptake value (SUV) over a 1-mL-volume sphere within an (18)F-FDG-positive lesion resulting in the highest possible value (SUVpeakW), was compared to that of an average SUV computed from the 40 hottest voxels, irrespective of their location within the lesion (SUVmax-40). METHODS A PET dynamic acquisition performed in 20 lung cancer lesions yielded for each SUV metric its mean value, relative measurement error and repeatability (MEr-R). RESULTS SUVpeakW mean value was significantly 9.66% lower than that of SUVmax-40 (P<0.0001). SUVpeakW and SUVmax-40 MEr-R were significantly lower than MEr-R of SUVmax (the hottest voxel): 9.35-13.21%, 8.84-12.49% versus 13.86-19.59% respectively (95%-CL; P<0.0001). Although being marginal, SUVpeakW MEr-R were not significantly greater than SUVmax-40 MEr-R (P = 0.086). CONCLUSION SUVmax-40 is more likely to represent the most metabolically active portions of tumors than SUVpeakW, with close variability performance.

Abstract

The performance of an average standard uptake value (SUV) over a 1-mL-volume sphere within an (18)F-FDG-positive lesion resulting in the highest possible value (SUVpeakW), was compared to that of an average SUV computed from the 40 hottest voxels, irrespective of their location within the lesion (SUVmax-40). METHODS A PET dynamic acquisition performed in 20 lung cancer lesions yielded for each SUV metric its mean value, relative measurement error and repeatability (MEr-R). RESULTS SUVpeakW mean value was significantly 9.66% lower than that of SUVmax-40 (P<0.0001). SUVpeakW and SUVmax-40 MEr-R were significantly lower than MEr-R of SUVmax (the hottest voxel): 9.35-13.21%, 8.84-12.49% versus 13.86-19.59% respectively (95%-CL; P<0.0001). Although being marginal, SUVpeakW MEr-R were not significantly greater than SUVmax-40 MEr-R (P = 0.086). CONCLUSION SUVmax-40 is more likely to represent the most metabolically active portions of tumors than SUVpeakW, with close variability performance.

Altmetrics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Nuclear Medicine
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2016
Deposited On:27 Nov 2015 12:17
Last Modified:05 Apr 2016 19:34
Publisher:Society of Nuclear Medicine
ISSN:0161-5505
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.2967/jnumed.115.161968
PubMed ID:26564325

Download

Full text not available from this repository.
View at publisher

TrendTerms

TrendTerms displays relevant terms of the abstract of this publication and related documents on a map. The terms and their relations were extracted from ZORA using word statistics. Their timelines are taken from ZORA as well. The bubble size of a term is proportional to the number of documents where the term occurs. Red, orange, yellow and green colors are used for terms that occur in the current document; red indicates high interlinkedness of a term with other terms, orange, yellow and green decreasing interlinkedness. Blue is used for terms that have a relation with the terms in this document, but occur in other documents.
You can navigate and zoom the map. Mouse-hovering a term displays its timeline, clicking it yields the associated documents.

Author Collaborations