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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-11525

Benden, C; Speich, R; Hofbauer, G F; Irani, S; Eich-Wanger, C; Russi, E W; Weder, W; Boehler, A (2008). Extracorporeal photopheresis after lung transplantation: a 10-year single-center experience. Transplantation, 86(11):1625-1627.

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Abstract

We report the largest single-center experience with extracorporeal photopheresis (ECP) for bronchiolitis obliterans syndrome (BOS) and recurrent acute rejection (AR) after lung transplantation. Lung transplant recipients undergoing ECP for BOS and recurrent AR were included (1997-2007). The rate of forced expiratory volume in 1 second (FEV1) decline was used as the primary measure and graft survival post-ECP as the secondary measure of efficacy. Twenty-four transplant recipients were included (BOS, n=12; recurrent AR, n=12). In recipients with BOS, decline in FEV1 was 112 mL/month before the start of ECP and 12 mL/month after 12 ECP cycles (P=0.011), mean (95% CI) change in rate of decline was 100 (28-171). Median patient survival was 7.0 (range, 3.0-13.6) years, median patient survival post-ECP 4.9 (range, 0.5-8.4) years. No ECP-related complications occurred. Extracorporeal photopheresis reduces the rate of lung function decline in recipients with BOS and is well tolerated. Furthermore, recipients with recurrent AR experience clinical stabilization. However, the underlying mechanism of ECP remains subject to further research.

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Pneumology
04 Faculty of Medicine > University Hospital Zurich > Clinic and Policlinic for Internal Medicine
04 Faculty of Medicine > University Hospital Zurich > Dermatology Clinic
04 Faculty of Medicine > University Hospital Zurich > Clinic for Thoracic Surgery
DDC:610 Medicine & health
Language:English
Date:2008
Deposited On:27 Jan 2009 10:34
Last Modified:27 Nov 2013 19:19
Publisher:Lippincott Wiliams & Wilkins
ISSN:0041-1337
Publisher DOI:10.1097/TP.0b013e31818bc024
PubMed ID:19077900
Citations:Web of Science®. Times Cited: 40
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Scopus®. Citation Count: 45

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