Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-11533
Chmiel, C; Speich, R; Hofer, M; Michel, D; Mertens, T; Weder, W; Boehler, A (2008). Ganciclovir/valganciclovir prophylaxis decreases cytomegalovirus-related events and bronchiolitis obliterans syndrome after lung transplantation. Clinical Infectious Diseases, 46(6):831-839.
BACKGROUND: Until recently, cytomegalovirus (CMV) infection represented a major threat to lung transplant recipients. Preliminary studies have shown that antiviral prophylaxis might improve the outcome for these patients. METHODS: We extended our initial pilot trial of prolonged prophylaxis with either oral ganciclovir (1 g 3 times per day) or valganciclovir (450 mg twice per day). The trial included 96 patients who were at risk for CMV-related events. RESULTS: CMV prophylaxis resulted in a significant decrease in CMV-related events (i.e., active infection and disease), from 75% in a control group and for 274 cases from the literature who did not receive prophylaxis to a cumulative incidence of 27% (P < .001). Only 11% of the prophylaxis recipients experienced CMV disease (P = .002). Moreover, at 5 years, there was a significant decrease in the rate of bronchiolitis obliterans syndrome, from 60% to 43% (P = .002), and an improved rate of survival, from 47% to 73% (P= .036), irrespective of the immunosuppressive regimen received. CMV strains with UL97 mutations were recovered from 7 of 12 analyzed cases, but the presence of this mutation had no impact on the severity of CMV disease. CONCLUSIONS: A regimen of prolonged ganciclovir or valganciclovir prophylaxis decreased the rate of active CMV infection and disease, reduced the incidence of bronchiolitis obliterans syndrome, and improved the survival rate. Drug-resistant CMV strains may occur, but such strains appeared to have no impact on the outcome of CMV-related events.
|Item Type:||Journal Article, refereed, original work|
|Communities & Collections:||04 Faculty of Medicine > University Hospital Zurich > Clinic for Pneumology|
04 Faculty of Medicine > University Hospital Zurich > Clinic and Policlinic for Internal Medicine
|DDC:||610 Medicine & health|
|Deposited On:||27 Jan 2009 12:03|
|Last Modified:||28 Nov 2013 02:09|
|Publisher:||University of Chicago Press|
|Additional Information:||Full text at http://www.journals.uchicago.edu/doi/pdf/10.1086/528689?cookieSet=1|
|Citations:||Web of Science®. Times cited: 44|
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