UZH-Logo

Maintenance Infos

Short courses of dual-strain probiotics appear to be effective in reducing necrotising enterocolitis


Guthmann, Florian; Arlettaz Mieth, Romaine P; Bucher, Hans Ulrich; Bührer, Christoph (2016). Short courses of dual-strain probiotics appear to be effective in reducing necrotising enterocolitis. Acta Paediatrica, 105(3):255-259.

Abstract

AIM: Prophylactic probiotics to reduce necrotising enterocolitis (NEC) are mostly given for at least 28 days or until discharge. We describe the effects of a shorter duration dosing strategy.
METHODS: Retrospective cohort study of neonates (birth weight 400-1,500 g) in three neonatal intensive care units in Switzerland and Germany that embarked on probiotic prophylaxis given for 10 or 14 days, employing a fixed combination (Lactobacillus acidophilus plus Bifidobacterium infantis, each 10(9) CFU/d) licensed as a drug in Switzerland. Probiotics were initiated upon discontinuation of antibiotics, or on day 1-3 in infants without antibiotics. Repeat probiotic courses were given whenever antibiotics had been instituted and were discontinued.
RESULTS: Birth weight and gestational age were similar in the two 24-month pre- and post-implementation cohorts. NEC rates fell from 33/633 (5.2%) to 8/591 infants alive at 3 days (1.4%; risk ratio (RR) 0.26, 95% confidence interval (CI) 0.12-0.55). The drop in NEC was significant both for infants of 400-999 g (6.4% to 2.5%) and 1,000-1,500 g birth weight (4.4% to 0.6%). Mortality was 5.1% (32/633) without, as opposed to 3.5% (21/591) with probiotics, respectively (RR 0.69, 95% CI 0.41-1.19).
CONCLUSION: Short courses of a dual-strain probiotics appear to be effective in reducing NEC. This article is protected by copyright. All rights reserved.

Abstract

AIM: Prophylactic probiotics to reduce necrotising enterocolitis (NEC) are mostly given for at least 28 days or until discharge. We describe the effects of a shorter duration dosing strategy.
METHODS: Retrospective cohort study of neonates (birth weight 400-1,500 g) in three neonatal intensive care units in Switzerland and Germany that embarked on probiotic prophylaxis given for 10 or 14 days, employing a fixed combination (Lactobacillus acidophilus plus Bifidobacterium infantis, each 10(9) CFU/d) licensed as a drug in Switzerland. Probiotics were initiated upon discontinuation of antibiotics, or on day 1-3 in infants without antibiotics. Repeat probiotic courses were given whenever antibiotics had been instituted and were discontinued.
RESULTS: Birth weight and gestational age were similar in the two 24-month pre- and post-implementation cohorts. NEC rates fell from 33/633 (5.2%) to 8/591 infants alive at 3 days (1.4%; risk ratio (RR) 0.26, 95% confidence interval (CI) 0.12-0.55). The drop in NEC was significant both for infants of 400-999 g (6.4% to 2.5%) and 1,000-1,500 g birth weight (4.4% to 0.6%). Mortality was 5.1% (32/633) without, as opposed to 3.5% (21/591) with probiotics, respectively (RR 0.69, 95% CI 0.41-1.19).
CONCLUSION: Short courses of a dual-strain probiotics appear to be effective in reducing NEC. This article is protected by copyright. All rights reserved.

Citations

2 citations in Web of Science®
1 citation in Scopus®
Google Scholar™

Altmetrics

Downloads

1 download since deposited on 15 Dec 2015
1 download since 12 months
Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Neonatology
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2016
Deposited On:15 Dec 2015 09:41
Last Modified:25 Nov 2016 01:00
Publisher:Wiley-Blackwell Publishing, Inc.
ISSN:0803-5253
Publisher DOI:https://doi.org/10.1111/apa.13280
PubMed ID:26600335

Download

[img]
Preview
Content: Accepted Version
Filetype: PDF
Size: 139kB
View at publisher

TrendTerms

TrendTerms displays relevant terms of the abstract of this publication and related documents on a map. The terms and their relations were extracted from ZORA using word statistics. Their timelines are taken from ZORA as well. The bubble size of a term is proportional to the number of documents where the term occurs. Red, orange, yellow and green colors are used for terms that occur in the current document; red indicates high interlinkedness of a term with other terms, orange, yellow and green decreasing interlinkedness. Blue is used for terms that have a relation with the terms in this document, but occur in other documents.
You can navigate and zoom the map. Mouse-hovering a term displays its timeline, clicking it yields the associated documents.

Author Collaborations