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Distinct haplotype structure at the innate immune receptor Toll-like receptor 2 (TLR2) across bank vole populations and lineages in Europe


Morger, Jennifer; Raberg, L; Hille, SM; Helsen, S; Štefka, J; Al-Sabi, MM; Kapel, CMO; Mappes, T; Essbauer, S; Ulrich, RG; Bartolommei, P; Mortelliti, A; Balčiauskas, L; van den Brink, NW; Rémy, A; Bajer, A; Cheprakov, M; Korva, M; García-Pérez, A; Biek, R; Withenshaw, S; Tschirren, Barbara (2015). Distinct haplotype structure at the innate immune receptor Toll-like receptor 2 (TLR2) across bank vole populations and lineages in Europe. Biological Journal of the Linnean Society, 116(1):124-133.

Abstract

Parasite-mediated selection may contribute to the maintenance of genetic variation at host immune genes over long time scales. To date, the best evidence for the long-term maintenance of immunogenetic variation in natural populations comes from studies on the major histocompatibility complex (MHC) genes, whereas evidence for such processes from other immune genes remains scarce. In the present study, we show that, despite pronounced population differentiation and the occurrence of numerous private alleles within populations, the innate immune gene Toll-like receptor 2 (TLR2) displays a distinct haplotype structure in 21 bank vole (Myodes glareolus) populations across Europe. Haplotypes from all populations grouped in four clearly differentiated clusters, with the three main clusters co-occurring in at least three previously described mitochondrial lineages. This pattern indicates that the distinct TLR2 haplotype structure may precede the split of the mitochondrial lineages 0.19–0.56 Mya and suggests that haplotype clusters at this innate immune receptor are maintained over prolonged time in wild bank vole populations.

Abstract

Parasite-mediated selection may contribute to the maintenance of genetic variation at host immune genes over long time scales. To date, the best evidence for the long-term maintenance of immunogenetic variation in natural populations comes from studies on the major histocompatibility complex (MHC) genes, whereas evidence for such processes from other immune genes remains scarce. In the present study, we show that, despite pronounced population differentiation and the occurrence of numerous private alleles within populations, the innate immune gene Toll-like receptor 2 (TLR2) displays a distinct haplotype structure in 21 bank vole (Myodes glareolus) populations across Europe. Haplotypes from all populations grouped in four clearly differentiated clusters, with the three main clusters co-occurring in at least three previously described mitochondrial lineages. This pattern indicates that the distinct TLR2 haplotype structure may precede the split of the mitochondrial lineages 0.19–0.56 Mya and suggests that haplotype clusters at this innate immune receptor are maintained over prolonged time in wild bank vole populations.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Institute of Evolutionary Biology and Environmental Studies
Dewey Decimal Classification:570 Life sciences; biology
590 Animals (Zoology)
Uncontrolled Keywords:balancing selection;diversity;gene evolution;immunogenetics;maintenance of genetic variation; Myodes glareolus ;parasite resistance;phylogeography;rodents; TLR2
Language:English
Date:5 June 2015
Deposited On:23 Dec 2015 10:38
Last Modified:06 Jun 2016 00:00
Publisher:Wiley-Blackwell Publishing, Inc.
ISSN:0024-4066
Funders:URPP Evolution in Action
Additional Information:The definitive version is available at http://onlinelibrary.wiley.com/
Publisher DOI:https://doi.org/10.1111/bij.12593
Official URL:http://link.springer.com/article/10.1007/s00265-015-1893-1/fulltext.html#copyrightInformation

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