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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-11741

Kiefer, C; Schroth, G; Gralla, J; Diehm, N; Baumgartner, I; Husmann, M (2009). A feasibility study on model-based evaluation of kidney perfusion measured by means of FAIR prepared true-FISP arterial spin labeling (ASL) on a 3-T MR scanner. Academic Radiology, 16(1):79-87.

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RATIONALE AND OBJECTIVES: A feasibility study on measuring kidney perfusion by a contrast-free magnetic resonance (MR) imaging technique is presented. MATERIALS AND METHODS: A flow-sensitive alternating inversion recovery (FAIR) prepared true fast imaging with steady-state precession (TrueFISP) arterial spin labeling sequence was used on a 3.0-T MR-scanner. The basis for quantification is a two-compartment exchange model proposed by Parkes that corrects for diverse assumptions in single-compartment standard models. RESULTS: Eleven healthy volunteers (mean age, 42.3 years; range 24-55) were examined. The calculated mean renal blood flow values for the exchange model (109 +/- 5 [medulla] and 245 +/- 11 [cortex] ml/min - 100 g) are in good agreement with the literature. Most important, the two-compartment exchange model exhibits a stabilizing effect on the evaluation of perfusion values if the finite permeability of the vessel wall and the venous outflow (fast solution) are considered: the values for the one-compartment standard model were 93 +/- 18 (medulla) and 208 +/- 37 (cortex) ml/min - 100 g. CONCLUSION: This improvement will increase the accuracy of contrast-free imaging of kidney perfusion in treatment renovascular disease.


9 citations in Web of Science®
16 citations in Scopus®
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Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Angiology
Dewey Decimal Classification:610 Medicine & health
Date:January 2009
Deposited On:06 Apr 2009 15:23
Last Modified:05 Apr 2016 12:54
Publisher DOI:10.1016/j.acra.2008.04.024
Official URL:http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B75BK-4V3H0B4-C-C&_cdi=12985&_user=5294990&_orig=search&_coverDate=01%2F31%2F2009&_sk=999839998&view=c&wchp=dGLzVtz-zSkzS&md5=163babe0fbc2da4f10d4e29529a26754&ie=/sdarticle.pdf
PubMed ID:19064215

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