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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-118

Willmann, R; Fuhrer, C (2002). Neuromuscular synaptogenesis: clustering of acetylcholine receptors revisited. Cellular and Molecular Life Sciences, 59(8):1296-1316.

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Clustering of neurotransmitter receptors in the postsynaptic membrane is critical for efficient synaptic transmission. During neuromuscular synaptogenesis, clustering of acetylcholine receptors (AChRs) is an early sign of postsynaptic differentiation. Recent studies have revealed that the earliest AChR clusters can form in the muscle independent of motorneurons. Neurally released agrin, acting through the muscle-specific kinase MuSK and rapsyn, then causes further clustering and localization of clusters underneath the nerve terminal. AChRs themselves are required for agrin-induced clustering of several postsynaptic proteins, most notably rapsyn. Once formed, AChR clusters are stabilized by several tyrosine kinases and by components of the dystrophin/utrophin glycoprotein complex, some of which also direct postnatal synaptic maturation such as formation of postjunctional folds. This review summarizes these recent results about AChR clustering, which indicate that early clustering can occur in the absence of nerves, that AChRs play an active role in the clustering process and that partly different mechanisms direct formation versus stabilization of AChR clusters.


54 citations in Web of Science®
59 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Brain Research Institute
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Date:1 August 2002
Deposited On:11 Feb 2008 12:12
Last Modified:05 Apr 2016 12:12
Additional Information:The original publication is available at www.springerlink.com.
Publisher DOI:10.1007/s00018-002-8509-4
Related URLs:http://www.springerlink.com/content/mma8ulv06rul5jpp/
PubMed ID:12363034

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