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Autophagy and autophagy-related proteins in the immune system


Shibutani, Shusaku T; Saitoh, Tatsuya; Nowag, Heike; Münz, Christian; Yoshimori, Tamotsu (2015). Autophagy and autophagy-related proteins in the immune system. Nature Immunology, 16(10):1014-1024.

Abstract

Autophagy is an intracellular bulk degradation system that is highly conserved in eukaryotes. The discovery of autophagy-related ('ATG') proteins in the 1990s greatly advanced the mechanistic understanding of autophagy and clarified the fact that autophagy serves important roles in various biological processes. In addition, studies have revealed other roles for the autophagic machinery beyond autophagy. In this Review, we introduce advances in the knowledge of the roles of autophagy and its components in immunity, including innate immunity, inflammatory responses and adaptive immunity.

Abstract

Autophagy is an intracellular bulk degradation system that is highly conserved in eukaryotes. The discovery of autophagy-related ('ATG') proteins in the 1990s greatly advanced the mechanistic understanding of autophagy and clarified the fact that autophagy serves important roles in various biological processes. In addition, studies have revealed other roles for the autophagic machinery beyond autophagy. In this Review, we introduce advances in the knowledge of the roles of autophagy and its components in immunity, including innate immunity, inflammatory responses and adaptive immunity.

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22 citations in Web of Science®
27 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > Institute of Experimental Immunology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:English
Date:October 2015
Deposited On:08 Jan 2016 10:01
Last Modified:05 Apr 2016 19:49
Publisher:Nature Publishing Group
ISSN:1529-2908
Additional Information:Review
Publisher DOI:https://doi.org/10.1038/ni.3273
PubMed ID:26382870

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