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Advances in allergen immunotherapy: aiming for complete tolerance to allergens


Akdis, Cezmi A; Akdis, Mübeccel (2015). Advances in allergen immunotherapy: aiming for complete tolerance to allergens. Science Translational Medicine, 7(280):280ps6.

Abstract

Allergen-specific immunotherapy (AIT) has been used for more than 100 years as a tolerance-inducing therapy for allergic diseases and represents a potentially curative method of treatment. AIT functions through multiple mechanisms, including regulating T and B cell responses, changing antibody isotypes, and decreasing mediator release and migration of eosinophils, basophils, and mast cells to affected tissues. Despite the relative success of AIT, attempts are being made to improve this therapy in order to overcome problems in standardization, efficacy, safety, long duration of treatment, and costs. These have led to the development of biotechnological products with successful clinical results.

Abstract

Allergen-specific immunotherapy (AIT) has been used for more than 100 years as a tolerance-inducing therapy for allergic diseases and represents a potentially curative method of treatment. AIT functions through multiple mechanisms, including regulating T and B cell responses, changing antibody isotypes, and decreasing mediator release and migration of eosinophils, basophils, and mast cells to affected tissues. Despite the relative success of AIT, attempts are being made to improve this therapy in order to overcome problems in standardization, efficacy, safety, long duration of treatment, and costs. These have led to the development of biotechnological products with successful clinical results.

Citations

15 citations in Web of Science®
18 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Swiss Institute of Allergy and Asthma Research
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:25 March 2015
Deposited On:21 Jan 2016 11:26
Last Modified:05 Apr 2016 19:53
Publisher:American Association for the Advancement of Science
ISSN:1946-6234
Publisher DOI:https://doi.org/10.1126/scitranslmed.aaa7390
PubMed ID:25810310

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