Delli Gatti, C; Osto, E; Kouroedov, A; Eto, M; Shaw, S; Volpe, M; Lüscher, T F; Cosentino, F (2008). Pulsatile stretch induces release of angiotensin II and oxidative stress in human endothelial cells: effects of ACE inhibition and AT1 receptor antagonism. Clinical and Experimental Hypertension, 30(7):616-627.
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Mechanical forces and the activation of the renin-angiotensin system (RAS) may alter the NO/O2(*-) balance, imparing endothelial nitric oxide (NO) availability. This study investigates the link between RAS and NO/O2(*-) balance in human aortic endothelial cells (HAEC) exposed to pulsatile stretch with and without ACE inhibitor quinaprilat or angiotensin II type 1 (AT(1)) receptor antagonist losartan. Pulsatile stretch increased Ang II levels and O2(*-) production, reducing NO release. RAS blockade with quinaprilat or losartan restored the balance between NO and O2(*-). These results provide a molecular basis for understanding the vascular protective effects of ACE inhibition and AT(1) receptor antagonism.
|Item Type:||Journal Article, refereed, original work|
|Communities & Collections:||04 Faculty of Medicine > University Hospital Zurich > Clinic for Cardiology|
|DDC:||610 Medicine & health|
|Deposited On:||03 Feb 2009 11:56|
|Last Modified:||27 Nov 2013 23:12|
|Publisher:||Taylor & Francis|
|Citations:||Web of Science®. Times Cited: 13|
Scopus®. Citation Count: 17
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