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Eosinophilic esophagitis as paraneoplastic syndrome in a patient with ganglioneuroblastoma


Prader, S; Spalinger, J; Caduff, J; Hürlimann, S; Rischewski, J (2015). Eosinophilic esophagitis as paraneoplastic syndrome in a patient with ganglioneuroblastoma. Klinische Pädiatrie, 227(3):173-175.

Abstract

A 16-month-old boy presented with failure to thrive despite sufficient caloric intake, hypersalivation, abdominal pain, chronic diarrhea and blepharitis. An eosinophilic esophagitis (EoE) was diagnosed by esophageal biopsy. Dietary restrictions and topical steroid treatment lead to no improvement. Further diagnostic work-up revealed an intrathoracal, paraspinal ganglioneuroblastoma. After operative extirpation of the tumour, all initial symptoms resolved. An esophageal control biopsy 4 weeks after tumour resection was normal. This is the first report of eosinophilic esophagitis as part of a paraneoplastic syndrome in a patient with a malignant disease other than a carcinoma.

Abstract

A 16-month-old boy presented with failure to thrive despite sufficient caloric intake, hypersalivation, abdominal pain, chronic diarrhea and blepharitis. An eosinophilic esophagitis (EoE) was diagnosed by esophageal biopsy. Dietary restrictions and topical steroid treatment lead to no improvement. Further diagnostic work-up revealed an intrathoracal, paraspinal ganglioneuroblastoma. After operative extirpation of the tumour, all initial symptoms resolved. An esophageal control biopsy 4 weeks after tumour resection was normal. This is the first report of eosinophilic esophagitis as part of a paraneoplastic syndrome in a patient with a malignant disease other than a carcinoma.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Children's Hospital Zurich > Medical Clinic
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:May 2015
Deposited On:29 Jan 2016 10:59
Last Modified:05 Apr 2016 19:57
Publisher:Georg Thieme Verlag
ISSN:0300-8630
Publisher DOI:https://doi.org/10.1055/s-0035-1547307
PubMed ID:25985452

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