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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-12223

Hoefflinghaus, T; Husmann, L; Valenta, I; Moonen, C; Gaemperli, O; Schepis, T; Namdar, M; Koepfli, P; Siegrist, P T; Kaufmann, P A (2008). Role of attenuation correction to discriminate defects caused by left bundle branch block versus coronary stenosis in single photon emission computed tomography myocardial perfusion imaging. Clinical Nuclear Medicine, 33(11):748-751.

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PURPOSE: To define the impact of attenuation correction (AC) on interpretation of perfusion abnormalities induced by left bundle branch block (LBBB) in myocardial perfusion imaging (MPI) and single photon emission computed tomography (SPECT). METHODS: Thirty-six patients with spontaneous and 12 with pacemaker (PM)-induced LBBB (mean age 68.6 +/- 9.7) underwent gated 1-day adenosine stress/rest Tc-99m tetrofosmin SPECT on a hybrid SPECT-CT dual-head detector camera with Hawkeye facility (Infinia, GE Healthcare, Milwaukee, WI). Images were analyzed using iterative reconstruction (IR) and AC by computerized tomography (IR-AC) and compared with filtered back protection (FBP) as a standard of reference. Defect extent and severity for the anterior, septal, apical, inferior, and lateral regions were assessed by computerized analysis. The combination of septal with anterior and/or apical perfusion defects was attributed to the typical LBBB-induced pattern. RESULTS: LBBB caused a typical perfusion pattern in 24 patients with spontaneous and in 10 with PM-induced LBBB, whereas MPI was normal in 14 patients. FBP revealed a partial reversibility of anterior (spontaneous LBBB) and apical-septal (spontaneous and PM-induced LBBB) defect severity. By IR-AC, LBBB caused comparable anteroseptal reversible perfusion defects (P < 0.05) but fixed apical defects. Apical-septal defect severity was higher and defect extent was larger in IR-AC compared with FBP (both P < 0.05). Defect extent was unchanged between rest and stress for both reconstructions. CONCLUSIONS: Spontaneous and PM-induced LBBB often induces typical perfusion defects in MPI at stress, partly reversible at rest. With IR-AC this typical pattern is more pronounced and less reversible, strengthening the confidence to discriminate such findings from ischemia.


5 citations in Web of Science®
8 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Nuclear Medicine
04 Faculty of Medicine > Center for Integrative Human Physiology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Date:November 2008
Deposited On:02 Feb 2009 17:37
Last Modified:05 Apr 2016 12:56
Publisher:Lippincott Wiliams & Wilkins
Publisher DOI:10.1097/RLU.0b013e318187ee9c
PubMed ID:18936604

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