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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-12295

Collin, M P; Hobbie , S N; Böttger , E C; Vasella, A (2008). Synthesis of 1,2,3-triazole analogues of lincomycin. Helvetica Chimica Acta, 91(10):1838-1848.

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Abstract

In search for new antibiotics we replaced the amide moiety of lincomycin 1 by a 1,2,3-triazole ring. The 1,2,3-triazoles 10a – 10k were obtained as single regioisomers by 9click reaction: of azide 5 with the alkyne 9k, derived from propyl hygric acid, and the alkyl, aryl, or cycloalkyl alkynes ribosomes 9a – 9j. The new analogues proved inactive towards wild-type and A2058G mutant.

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Medical Microbiology
DDC:570 Life sciences; biology
610 Medicine & health
Language:English
Date:2008
Deposited On:03 Feb 2009 10:44
Last Modified:27 Nov 2013 17:44
Publisher:Verlag Helvetica Chimica Acta
ISSN:0018-019X
Publisher DOI:10.1002/hlca.200890196
Citations:Web of Science®. Times Cited: 10
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