Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-12295
Collin, M P; Hobbie, S N; Böttger, E C; Vasella, A (2008). Synthesis of 1,2,3-triazole analogues of lincomycin. Helvetica Chimica Acta, 91(10):1838-1848.
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In search for new antibiotics we replaced the amide moiety of lincomycin 1 by a 1,2,3-triazole ring. The 1,2,3-triazoles 10a – 10k were obtained as single regioisomers by 9click reaction: of azide 5 with the alkyne 9k, derived from propyl hygric acid, and the alkyl, aryl, or cycloalkyl alkynes ribosomes 9a – 9j. The new analogues proved inactive towards wild-type and A2058G mutant.
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|Item Type:||Journal Article, refereed, original work|
|Communities & Collections:||04 Faculty of Medicine > Institute of Medical Microbiology|
|Dewey Decimal Classification:||570 Life sciences; biology
610 Medicine & health
|Deposited On:||03 Feb 2009 09:44|
|Last Modified:||05 Apr 2016 12:56|
|Publisher:||Verlag Helvetica Chimica Acta|
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