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Is salivary estriol detectable in very early pregnancy?


Wingeier, Manuela; La Marca-Ghaemmaghami, Pearl; Zimmermann, Roland; Ehlert, Ulrike (2017). Is salivary estriol detectable in very early pregnancy? Journal of Maternal-Fetal & Neonatal Medicine, 30(2):228-232.

Abstract

OBJECTIVE: Estriol (E3) is produced by the placenta and is important for early pregnancy maintenance. In blood, E3 can be detected from the 8(th) week of pregnancy. Under the influence of the hypothalamic-pituitary-adrenal (HPA) axis hormone ACTH, E3 levels increase sharply after the 10(th) week. Although E3 can be reliably analyzed in saliva, up to now information about the concentrations during the first trimester is missing. The aim of this study was to verify whether the sensitivity of a newly developed enzyme immunoassay is sufficient for the determination of salivary E3 (sE3) in very early pregnancy.
METHODS: Saliva samples were collected at home, once weekly in 25 healthy pregnant women from the 6(th) week of gestation to the end of the first trimester.
RESULTS: sE3 was detectable from the beginning of the 6(th) pregnancy week (M = 3.17 pg/ml, SD = 2.13). A steep significant increase between the 7(th) and the 8(th) week (P = .029) and again between the 10(th) and the 11(th) week (P = .001) was apparent.
CONCLUSION: How concentrations of sE3 can be measured during very early pregnancy and may serve as a promising, easily assessable marker for future research on the mechanisms of healthy pregnancy.

Abstract

OBJECTIVE: Estriol (E3) is produced by the placenta and is important for early pregnancy maintenance. In blood, E3 can be detected from the 8(th) week of pregnancy. Under the influence of the hypothalamic-pituitary-adrenal (HPA) axis hormone ACTH, E3 levels increase sharply after the 10(th) week. Although E3 can be reliably analyzed in saliva, up to now information about the concentrations during the first trimester is missing. The aim of this study was to verify whether the sensitivity of a newly developed enzyme immunoassay is sufficient for the determination of salivary E3 (sE3) in very early pregnancy.
METHODS: Saliva samples were collected at home, once weekly in 25 healthy pregnant women from the 6(th) week of gestation to the end of the first trimester.
RESULTS: sE3 was detectable from the beginning of the 6(th) pregnancy week (M = 3.17 pg/ml, SD = 2.13). A steep significant increase between the 7(th) and the 8(th) week (P = .029) and again between the 10(th) and the 11(th) week (P = .001) was apparent.
CONCLUSION: How concentrations of sE3 can be measured during very early pregnancy and may serve as a promising, easily assessable marker for future research on the mechanisms of healthy pregnancy.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Obstetrics
06 Faculty of Arts > Institute of Psychology
Dewey Decimal Classification:150 Psychology
Uncontrolled Keywords:DoktoratPsych Erstautor
Language:English
Date:2017
Deposited On:29 Mar 2016 12:26
Last Modified:25 Nov 2016 02:00
Publisher:Informa Healthcare
ISSN:1476-4954
Publisher DOI:https://doi.org/10.3109/14767058.2016.1169522
PubMed ID:27002285

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